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Type 1 diabetes prevalence increasing globally and regionally: the role of natural selection and life expectancy at birth
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Other responses

  • Published on:
    Re:The genes associated with a high risk of type 1 diabetes are becoming less common
    We thank colleagues for their critical comments that help to clarify relationships we have studied. We are not concerned with the frequency of what specific genes, high-risk or not, has increased recently. We are just making a general statement that with relaxed natural selection detrimental mutations may accumulate. The paper by Witas et al. cited by our critics uses the same rationale as we do when suggesting changes in type 1 d...
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    Conflict of Interest:
    None declared.
  • Published on:
    The genes associated with a high risk of type 1 diabetes are becoming less common
    • Sarah G Howard, National Coordinator, Diabetes and Obesity Working Group
    • Other Contributors:
      • Timothy G. Howard, PhD
    In the article, "Type 1 diabetes prevalence increasing globally and regionally: The role of natural selection and life expectancy at birth" (You and Henneberg 2016), the authors find a correlation between worldwide type 1 diabetes prevalence and both life expectancy at birth and the "Biological State Index" (Ibs), a measure of population reproductive success. Based on these findings, they argue that "the correlation of Ibs to the...
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    Conflict of Interest:
    None declared.