@article {Ratzki-Leewinge000503, author = {Alexandria Ratzki-Leewing and Stewart B Harris and Selam Mequanint and Sonja M Reichert and Judith Belle Brown and Jason Edward Black and Bridget L Ryan}, title = {Real-world crude incidence of hypoglycemia in adults with diabetes: Results of the InHypo-DM Study, Canada}, volume = {6}, number = {1}, elocation-id = {e000503}, year = {2018}, doi = {10.1136/bmjdrc-2017-000503}, publisher = {BMJ Specialist Journals}, abstract = {Objective Very few real-world studies have been conducted to assess the incidence of diabetes-related hypoglycemia. Moreover, there is a paucity of studies that have investigated hypoglycemia among people taking secretagogues as a monotherapy or in combination with insulin. Accordingly, our research team developed and validated the InHypo-DM Person with Diabetes Mellitus Questionnaire (InHypo-DMPQ) with the aim of capturing the real-world incidence of self-reported, symptomatic hypoglycemia. The questionnaire was administered online to a national sample of Canadians (>=18 years old) with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) treated with insulin and/or insulin secretagogues.Research design and methods Self-report data obtained from the InHypo-DMPQ were descriptively analyzed to ascertain the crude incidence proportions and annualized incidence densities (rates) of 30-day retrospective non-severe and 1-year retrospective severe hypoglycemia, including daytime and nocturnal events.Results A total of 552 people (T2DM: 83\%; T1DM: 17\%) completed the questionnaire. Over half (65.2\%) of the total respondents reported experiencing at least one event (non-severe or severe) at an annualized crude incidence density of 35.1 events per person-year. The incidence proportion and rate of non-severe events were higher among people with T1DM versus T2DM (77\% and 55.7 events per person-year vs 54\% and 28.0 events per person-year). Severe hypoglycemia was reported by 41.8\% of all respondents, at an average rate of 2.5 events per person-year.Conclusions The results of the InHypo-DMPQ, the largest real-world investigation of hypoglycemia epidemiology in Canada, suggest that the incidence of hypoglycemia among adults with diabetes taking insulin and/or insulin secretagogues is higher than previously thought.}, URL = {https://drc.bmj.com/content/6/1/e000503}, eprint = {https://drc.bmj.com/content/6/1/e000503.full.pdf}, journal = {BMJ Open Diabetes Research and Care} }