Definitions of treatment modifications
| Treatment modification | Definition |
|---|---|
| Dose escalation | Continuation of index treatment with dose escalation of ≥25% between consecutive claims of statin |
| Dose reduction | Continuation of index treatment with dose reduction of ≥25% between consecutive claims of statin |
| Augmentation | Continuation of index treatment with addition of a new non-statin medication (or addition of a statin medication for those with ezetimibe as index treatment) |
| Subtraction | Moved from combination treatment to a subset of combination treatment/monotherapy within end of days’ supply plus 60-day grace period |
| Switch to non-index statin | Initiation of non-index statin postindex treatment date (termination of index statin treatment was assumed if days supply overlapped) |
| Switch to non-statin | Initiation of non-statin postindex treatment date |
| Reinitiation | Discontinuation of all components of index treatment and reinitiate index treatment after end of days supply plus 60-day grace period |
| Permanent discontinuation | Discontinuation of all components of index treatment through end of follow-up period |