Table 2

Association between baseline characteristics at diagnosis and change in medication count between diagnosis and 5 years in the ADDITION-UK cohort

	Change in total medication count		Change in diabetes medication		Change in CVD medication		Change in other medication
	β*	95% CI	IRR*	95% CI	β*	95% CI	β*	95% CI
Number of medications at diagnosis†	−0.49	−0.56 to −0.42	–	–	−0.50	−0.56 to −0.44	−0.30	−0.37 to −0.22
Male gender	−0.25	−0.57 to 0.06	0.86	0.75 to 0.99	−0.11	−0.33 to 0.10	0.12	−0.10 to 0.34
Intensive treatment arm	0.44	0.10 to 0.78	1.14	1.01 to 1.30	0.39	0.09 to 0.69	−0.08	−0.30 to 0.13
Age at diagnosis (years)	−0.03	−0.05 to −0.01	0.96	0.95 to 0.97	−0.02	−0.03 to 0.002	0.02	0.01 to 0.04
Modelling 10-year UKPDS CVD risk (%)	0.04	0.02 to 0.05	1.02	1.01 to 1.03	0.02	0.01 to 0.03	0.00	−0.01 to 0.01

*IRR, Incidence Rate Ratio from a Poisson regression model; β, Regression coefficient from a linear regression model.
†Number of medications of the medication type that is the dependent variable in that columns regression.
CVD, cardiovascular disease; UKPDS, UK Prospective Diabetes Study.