DIAGRAM-derived association results for type 2 diabetes with respect to the loci on interest
| Variants previously published for GWAS of any trait | |||||||||||
| SNP | CHROMOSOME | POSITION | RISK_ALLELE | OTHER_ALLELE | P_VALUE | OR | OR_95L | OR_95U | N_CASES | N_CONTROLS | Gene |
| rs7901695 | 10 | 114 744 078 | C | T | 2.50E-65 | 1.37 | 1.32 | 1.42 | 12 171 | 56 862 | TCF7L2 * |
| rs46522 | 17 | 44 343 596 | T | C | 3.20E-04 | 1.07 | 1.03 | 1.11 | 9580 | 53 810 | UBE2Z-GIP-ATP5G1-SNF8 |
| Variants not previously reported by GWAS of type 2 diabetes | |||||||||||
| SNP | CHROMOSOME | POSITION | RISK_ALLELE | OTHER_ALLELE | P_VALUE | OR | OR_95L | OR_95U | N_CASES | N_CONTROLS | Gene |
| rs4780476 | 16 | 12 769 508 | A | C | 4.10E-05 | 1.1 | 1.05 | 1.15 | 6634 | 49 797 | CPPED1 |
These loci survived correction for multiple testing based on the constraints derived from working with the HCT116 ChIP-seq 5 kb gene list and integrating with tag-SNPs coinciding with genes on that list.
*Locus previously reported to be associated with type 2 diabetes.
ChIP, chromatin immunoprecipitation; SNP, single nucleotide polymorphism.