Haplotype 1 | Haplotype 2 | Anti-GAD | OR (95% CI) | p Value‡ | ||
---|---|---|---|---|---|---|

HLA DQA1-DQB1 | HLA DQA1-DQB1 | Negative N=151 | Positive N=75 | |||

Very high risk | 0301–0302 | 0501–0201 | 3 (2.0) | 8 (10.7) | 9.57 (2.16 to 42.16) | <0.01 |

High risk | 0301–0302 0501–0201 X*-0302 | Z† Z X-X | 61 (40.4) | 37 (49.3) | 2.21 (1.02 to 4.77) | 0.04 |

Neutral | X-X | X-X | 45 (29.8) | 18 (24.0) | 1.46 (0.62 to 3.40) | 0.39 |

Strong protective | X-0602 X-0602 X-0602 X-0603 X-0603 X-0603 | X-0603 X-0302 X-X X-0602 X-0302 X-X | 42 (27.8) | 12 (16.0) | 1.00 |

Data are given as numbers (%).

*X means a non-defined allele, but does not exclude potential homozygosity.

†Z means any haplotype, defined and non-defined, except

*DQA1*0301*-*DQB1*0302*and*DQA1*0501*-*DQB1*0201*; however, it does not exclude potential homozygosity.‡p Value calculated from logistic regression, corrected for age and BMI at HUNT2, sex, and first-degree family history of diabetes.

BMI, body mass index; GAD, glutamic acid decarboxylase.