Partially and fully adjusted ORs and 95% CI for predictors of LEA
| Variable | Partially adjusted OR* | p Value | Fully adjusted OR† | p Value |
|---|---|---|---|---|
| Demographics | ||||
| Age | 1 (0.9 to 1.1) | 0.1 | 1 (0.9 to 1.1) | 0.20 |
| Male | 1.3 (0.6 to 2.6) | 0.5 | 1.3 (0.6 to 2.6) | 0.50 |
| Lower SES | 3.9 (2.0 to 7.5) | <0.00 | 1.7 (0.7 to 4.1) | 0.30 |
| Single | 3.7 (1.9 to 7.2) | <0.00 | ||
| Timing of first contact with any secondary healthcare services that manage diabetes | ||||
| None or within 1 year prior to event | Reference | Reference | ||
| Within 2–3 years prior to event | 1.4 (0.6 to 3.5) | 0.5 | 1.3 (0.5 to 3.4) | 0.50 |
| Within 4–7 years prior to event | 1.7 (0.8 to 3.3) | 0.1 | 1.6 (0.8 to 3.3) | 0.20 |
| Cardiovascular risk factors | ||||
| Smoker | 1.7 (0.9 to 3.2) | 0.1 | 1.1 (0.6 to 2.0) | 0.80 |
| Hypertension | 1.7 (0.9 to 3.3) | 0.10 | ||
| Comorbidities | ||||
| CKD | 2.6 (1.4 to 4.9) | 0.002 | 2.6 (1.4 to 4.8) | 0.03 |
| Retinopathy | 0.4 (0.2 to 0.8) | 0.01 | 0.4 (0.2 to 0.7) | 0.01 |
| HbA1c | ||||
| 3 years prior to event (1 unit change) | 1.3 (1.1 to 1.5) | 0.001 | 1.3 (1.1 to 1.5) | <0.00 |
*Partially adjusted for age, timing of first contact with any secondary healthcare services that manage diabetes, variables used for frequency matching, and those variables significant on univariate analysis.
†Fully adjusted model also including SES and smoking.
CKD, chronic kidney disease; HbA1c, glycated hemoglobin; LEA, lower extremity amputation; SES, socioeconomic status.