Baseline data for patients with T2DM using 1:5 matching with propensity score for each comparison
| Metformin versus SU | Metformin versus meglitinide | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Metformin | SU | Mean difference | Standardized difference | p Value | Metformin | Meglitinide | Mean difference | Standardized difference | p Value | |
| Number | 3585 | 717 | 1090 | 218 | ||||||
| Propensity score | 0.106±0.081 | 0.105±0.079 | 0.001 | 0.01 | 0.8 | 0.0431±0.041 | 0.0439±0.041 | −0.0008 | −0.02 | 0.8 |
| Age | 71.02±8.9 | 71.01±10.4 | 0.01 | 0.01 | 0.9 | 71.5±8.9 | 71.4±10.4 | 0.1 | 0.01 | 0.9 |
| Diabetes duration | 4.4±4.1 | 4.6±3.8 | −0.2 | 0.03 | 0.4 | 5.0±5.1 | 4.9±4.5 | 0.1 | 0.03 | 0.7 |
| HbA1c | 56.0±12.2 | 55.8±10.2 | 0.2 | 0.02 | 0.7 | 55.9±11.9 | 56.2±12.2 | −0.3 | −0.02 | 0.8 |
| BMI | 27.9±3.5 | 27.9±4.3 | 0.0 | 0.01 | 0.9 | 27.5±3.8 | 27.3±4.7 | 0.2 | 0.04 | 0.5 |
| eGFR | 77.6±17.4 | 78.0±23.6 | −0.4 | −0.02 | 0.6 | 76.9±18.0 | 77.5±23.6 | −0.6 | 0.03 | 0.7 |
| Male gender | 59.8 | 59.3 | 0.5 | −0.01 | 0.8 | 68.3 | 68.4 | −0.1 | 0.01 | 0.9 |
| Previous CVD | 15.9 | 19.4 | 3.5 | −0.09 | 0.03 | 16.5 | 15.1 | 1.4 | 0.04 | 0.6 |
| Previous CHF | 4.3 | 4.7 | −0.4 | −0.02 | 0.6 | 6.1 | 6.4 | −0.3 | −0.02 | 0.8 |
| Atrial fibrillation | 7.7 | 7.3 | 0.4 | 0.02 | 0.7 | 9.3 | 11.0 | −1.7 | −0.06 | 0.4 |
| Education score 1–3 | 1.72±0.72 | 1.75±0.73 | −0.03 | −0.04 | 0.3 | 1.72±0.72 | 1.71±0.77 | 0.01 | 0.01 | 0.7 |
| Psychiatric drugs | 20.5 | 22.0 | −1.5 | −0.04 | 0.4 | 19.8 | 22.9 | −3.1 | −0.08 | 0.3 |
| Multidose | 1.1 | 1.8 | −0.7 | −0.06 | 0.11 | 1.0 | 0.5 | 0.5 | 0.06 | 0.4 |
| Start year, mean | 2008.2±1.3 | 2008.2±1.3 | 0.0 | 0.02 | 0.6 | 2007.8±1.3 | 2007.8±1.2 | 0.0 | −0.021 | 0.9 |
Data given as means±SD or frequencies (%).
Standardized difference: for continuous variables (means and SDs estimated as customary): (mean A—mean B)/sqrt ((SD_A2+SD_B2)/2; for categorical variables: (freq A—freq B)/sqrt ((freq A * [1-freq A])+(freq B * [1-freq B]))/2.
BMI, body mass index; CHF, congestive heart failure; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; multidose: multidose drug dispensing; SU, sulfonylurea; T2DM, type 2 diabetes mellitus.