Model 1 | Model 2 | Model 3 | Model 4 | |||||
---|---|---|---|---|---|---|---|---|
HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | |
Continuous variables | ||||||||
HbA1cVIM (1SD increment) | 1.33 (1.07 to 1.65) | 0.011 | NA | NA | 1.28 (1.02 to 1.61) | 0.035 | NA | NA |
SBPVIM (1SD increment) | NA | NA | 1.33 (1.08 to 1.63) | 0.008 | 1.27 (1.03 to 1.57) | 0.026 | NA | NA |
Categorical variables | ||||||||
Low HbA1cVIM and low SBPVIM | NA | NA | NA | NA | NA | NA | 1 | |
Low HbA1cVIM and high SBPVIM | NA | NA | NA | NA | NA | NA | 1.77 (0.90 to 3.51) | 0.10 |
High HbA1cVIM and low SBPVIM | NA | NA | NA | NA | NA | NA | 1.72 (0.82 to 3.63) | 0.15 |
High HbA1cVIM and high SBPVIM | NA | NA | NA | NA | NA | NA | 2.19 (1.12 to 4.29) | 0.022 |
All models were adjusted for mean HbA1c, mean SBP, number of visits (ln-transformed), age, sex, diabetes duration, BMI, TC/HDL-C, eGFR, baseline smoking status, baseline alcohol intake, baseline use of insulin, and baseline use of antihypertensive agents.
BMI, body mass index; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HDL-C, high-density lipoprotein cholesterol; NA, not applicable; SBP, systolic blood pressure; TC, total cholesterol; VIM, variation independent of mean.