Multivariate Cox proportional hazard models for the incidence of CVD in association with HbA1cCV and SBPCV as continuous and categorical variables divided by their respective median values
| Model 1 | Model 2 | Model 3 | Model 4 | |||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Continuous variables | ||||||||
| HbA1cCV (1SD increment) | 1.39 (1.10 to 1.76) | 0.006 | NA | NA | 1.33 (1.04 to 1.70) | 0.024 | NA | NA |
| SBPCV (1SD increment) | NA | NA | 1.33 (1.07 to 1.63) | 0.009 | 1.26 (1.02 to 1.57) | 0.032 | NA | NA |
| Categorical variables | ||||||||
| Low HbA1cCV and low SBPCV | NA | NA | NA | NA | NA | NA | 1 | |
| Low HbA1cCV and high SBPCV | NA | NA | NA | NA | NA | NA | 2.55 (1.22 to 5.32) | 0.013 |
| High HbA1cCV and low SBPCV | NA | NA | NA | NA | NA | NA | 2.64 (1.16 to 6.00) | 0.020 |
| High HbA1cCV and high SBPCV | NA | NA | NA | NA | NA | NA | 3.08 (1.45 to 6.55) | 0.003 |
All models were adjusted for mean HbA1c, mean SBP, number of visits (ln-transformed), age, sex, diabetes duration, BMI, TC/HDL-C, eGFR, baseline smoking status, baseline alcohol intake, baseline use of insulin, and baseline use of antihypertensive agents.
BMI, body mass index; CV, coefficient of variation; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HDL-C, high-density lipoprotein cholesterol; NA, not applicable; SBP, systolic blood pressure; TC, total cholesterol.