Incidence rates of myocardial infarction or ischemic stroke by sample characteristics
| Subgroups | Myocardial infarction or ischemic stroke | |||||
|---|---|---|---|---|---|---|
| Incidence rate per 1000 person-years | IRR | (95% CI) | ||||
| NSAID users | NSAIDs non-users | |||||
| IR | (95% CI) | IR | (95% CI) | |||
| Entire sample | 31.54 | (31.52 to 31.57) | 25.98 | (25.96 to 26.01) | 1.21 | (1.17 to 1.26) |
| Gender | ||||||
| Male | 33.84 | (33.80 to 33.88) | 27.14 | (27.11 to 27.17) | 1.25 | (1.18 to 1.32) |
| Female | 29.42 | (29.38 to 29.46) | 24.88 | (24.86 to 24.92) | 1.18 | (1.12 to 1.25) |
| Age group, years | ||||||
| 65–69 | 22.46 | (22.42 to 22.50) | 20.06 | (20.03 to 20.09) | 1.12 | (1.03 to 1.22) |
| 70–74 | 30.41 | (30.36 to 30.46) | 28.70 | (28.66 to 28.75) | 1.06 | (0.98 to 1.15) |
| 75–79 | 38.67 | (38.60 to 38.73) | 30.89 | (30.85 to 30.96) | 1.25 | (1.15 to 1.36) |
| 80– | 39.24 | (39.18 to 39.31) | 27.43 | (27.40 to 27.48) | 1.43 | (1.32 to 1.55) |
| Previous diagnosis | ||||||
| Hypertension | 33.65 | (33.61 to 33.68) | 27.36 | (27.34 to 27.39) | 1.23 | (1.17 to 1.29) |
| Dyslipidemia | 30.67 | (30.63 to 30.72) | 25.78 | (25.75 to 25.82) | 1.19 | (1.11 to 1.27) |
| Coronary artery disease | 42.63 | (42.51 to 42.74) | 34.31 | (34.23 to 34.41) | 1.24 | (1.10 to 1.41) |
| Heart failure | 41.95 | (41.82 to 42.08) | 33.00 | (32.92 to 33.11) | 1.27 | (1.10 to 1.47) |
| Atrial fibrillation/flutter | 43.34 | (43.13 to 43.55) | 26.01 | (25.89 to 26.17) | 1.67 | (1.30 to 2.14) |
| Osteoarthritis | 34.15 | (34.07 to 34.23) | 28.85 | (28.80 to 28.92) | 1.18 | (1.07 to 1.31) |
| Rheumatoid arthritis | 28.37 | (28.15 to 28.59) | 23.14 | (22.99 to 23.34) | 1.23 | (0.85 to 1.78) |
| Chronic liver disease | 29.07 | (29.01 to 29.13) | 23.06 | (23.02 to 23.11) | 1.26 | (1.14 to 1.39) |
| Chronic renal disease | 40.74 | (40.60 to 40.87) | 22.85 | (22.78 to 22.95) | 1.78 | (1.50 to 2.12) |
| Medication use | ||||||
| Antihypertensive agent | 33.19 | (33.16 to 33.22) | 27.15 | (27.12 to 27.17) | 1.22 | (1.17 to 1.28) |
| Anticoagulant | 42.20 | (42.10 to 42.31) | 30.31 | (30.25 to 30.40) | 1.39 | (1.23 to 1.57) |
| Antiplatelet agent | 45.64 | (45.56 to 45.73) | 39.16 | (39.11 to 39.24) | 1.17 | (1.07 to 1.27) |
| Aspirin | 34.49 | (34.45 to 34.54) | 29.77 | (29.74 to 29.81) | 1.16 | (1.09 to 1.23) |
| Proton pump inhibitor | 34.36 | (34.25 to 34.47) | 26.32 | (26.25 to 26.42) | 1.31 | (1.12 to 1.52) |
| Gastroprotective agent | 33.44 | (33.40 to 33.48) | 28.27 | (28.25 to 28.31) | 1.18 | (1.12 to 1.25) |
| Corticosteroid | 33.42 | (33.35 to 33.49) | 26.33 | (26.29 to 26.39) | 1.27 | (1.16 to 1.39) |
| SSRI | 38.77 | (38.65 to 38.89) | 31.60 | (31.52 to 31.71) | 1.23 | (1.06 to 1.42) |
IR, incidence rate; IRR, incidence rate ratio; NSAID, non-steroidal anti-inflammatory drug; SSRI, selective serotonin reuptake inhibitor.