Table 1

Virus replication and virus-induced islet disintegration in different donors

Donor number	Strain of CVB (day of termination)	Islet disintegration* (graded from 0 to 4)	Titer change† from day 0
1	Adr (6 dpi)	0	+4
1	V89-4557 (6 dpi)	3–4	+4
2	VD2921 (4 dpi)	0	+3
	V89-4557 (4 dpi)	0	+2.5
	V89-4557 (7 dpi)	3	+4.5
3	Adr (7 dpi)	0	+3.5
3	VD2921 (7 dpi)	0	+3.5
4	E2-Yoon (7 dpi)	3	+3
4	VD2921 (7 dpi)	2	+6
5	E2-Yoon (4 dpi)	2	+1.5
	E2-Yoon (7 dpi)	3–4	+2
	V89-4557 (7 dpi)	2	+2.5
6	E2-Yoon (6 dpi)	3–4	+2.5
7	E2-Yoon (6 dpi)	0	+2
8	E2-Yoon (6 dpi)	3	+2.5
9	VD2921 (6 dpi)	2	+4.5
	V89-4557 (6 dpi)	3–4	+4
	E2-Yoon (6 dpi)	3–4	+3
10	VD2921 (6 dpi)	2	+5
	V89-4557 (6 dpi)	3–4	+6
	E2-Yoon (6 dpi)	2	+2.5

*Virus-induced islet disintegration evaluated under a light microscope.
†Determined by TCID50 titration and presented as logTCID₅₀/200 µL.
CVB, coxsackievirus B; Dpi, days postinfection; TCID, tissue culture infectious dose₅₀.