Baseline characteristics of the subjects studied
| Variables | Healthy (n=10) | IGT+reduced FPIS (n=8) | IGT + preserved FPIS (n=14) | p |
| Gender (men n, %) | 1 (10) | 3 (37.5) | 8 (57.1) | 0.06 |
| Age (years) | 50.1±7.35 | 49.6±6.9 | 52.2±6.3 | 0.54 |
| Height (m) | 1.55±0.07 | 1.59±0.08 | 1.61±0.07 | 0.22 |
| Weight (kg) | 68.02±9.5 | 68.1±5.9 | 72.2±8.3 | 0.41 |
| BMI (kg/m2) | 27.9±2.0 | 26.7±1.6 | 27.7±2.6 | 0.23 |
| Glucose 0’ | 78.2±12.1 | 103.5±8.9 | 88.0±17.4 | 0.004 |
| Insulin 0’ | 7.5 (5.0–12.5) | 13.8 (10.2–16.0) | 13.9 (7.7–20.4) | 0.098 |
| TC (mg/dL) | 190.2±37.8 | 189.1±33.9 | 201.1±50.2 | 0.79 |
| HDL (mg/dL) | 41.2±10.1 | 38.0±8.9 | 40.8±13.5 | 0.77 |
| LDL (mg/dL) | 121.2±28.9 | 121.3±31.2 | 120.1±34.7 | 0.99 |
| Fatty acids (mmol/L) | 0.61±0.18 | 0.70±0.29 | 0.64±0.23 | 0.94 |
| Alpha-amino nitrogen (mmol/L) | 0.9 (0.8–6.3) | 0.95 (0.64–1.46) | 1.09 (0.83–1.33) | 0.54 |
| Adiponectin (µg/mL) | 13.8±6.6 | 9.1±4.5 | 9.5±6.5 | 0.23 |
| VLDL (TG) | 135.5±49.4 | 163.3±73.1 | 185.6±137.1 | 0.84 |
| HOMA2 beta secretion % | 144.5±56.1 | 121.1±29.6 | 190.1±65.5 | 0.020 |
| HOMA2 sensitivity % | 111.4±68 | 52.1±19.7 | 48.9±20.1 | 0.083 |
| HOMA2-IR | 1.33±0.85 | 2.23±1.08 | 2.45±1.19 | 0.083 |
The results are expressed as mean±SD for normally distributed variables, and medians (IQR) for variables with non-parametric distribution. To make the comparison between the 3 groups, Kruskal-Wallis test was used.
Glucose in mg/dL; insulin in µIU/mL.
Measurement of glucose and insulin after intravenous glucose load.
BMI, body mass index; FPIS, first-phase insulin secretion; HDL, high-density lipoprotein; HOMA2, Homeostasis Model Assessment 2; IGT, impaired glucose tolerance; LDL, low-density lipoprotein; TC, total cholesterol; TG, triglycerides; VLDL, very-low density, lipoprotein.