Table 3

Mean change from baseline of selected metabolic variables according to use of statins

	Placebo			Metformin			Lifestyle
	Statin use	No statin use	p	Statin use	No statin use	p	Statin use	No statin use	p
Fasting glucose (mg/dL)	3.0	1.9	0.04	−0.3	−1.3	0.03	0.8	−0.4	0.007
Two-hour glucose (mg/dL)	−2.2	−3.9	0.38	−2.8	−7.3	0.01	−5.6	−10.9	0.001
Glycated hemoglobin (%)	0.04	−0.01	<0.01	−0.03	−0.09	<0.001	−0.05	−0.11	<0.001
Insulinogenic Index	−0.21	3.83	0.42	−7.45	−3.85	0.44	−8.54	1.66	0.01
Fasting insulin (µU/mL)	2.76	2.61	0.83	−1.44	−0.93	0.43	0.64	−0.19	0.16
Body mass index (kg/m²)	0.14	0.12	0.84	−0.29	−0.53	0.04	−0.76	−0.92	0.06

Mean changes from baseline are estimated with adjustment for baseline value from mixed models according to use of statin at time of the assessment with p values to indicate difference by statin therapy within treatment groups. Changes after the development of diabetes were excluded in the analyses.