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Anticardiolipin antibodies in children and adolescents with insulin-dependent diabetes mellitus

  • Endocrinology
  • Original Paper
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Abstract

Anticardiolipin antibodies were determined in 29 diabetic children and adolescents, aged 3.9–26.8 years, with disease duration from 1 month to 19 years. Anti-islet cell antibodies (ICA-IgG and CF-ICA), anti-insulin antibodies (IAA), antithyroid antibodies and non organ-specifc (NOSA) antibodies were also determined. Patients were grouped according to insulin-dependent diabetes mellitus (IDDM) duration: group I (n=11)<6 months, and group II (n=18)>5 years. Eleven of group II patients showed precocious signs of micro-angiopathic complications. Forty-two age- and sex-matched healthy subjects served as controls. IgG and IgM anticardiolipin antibodies were evaluated by ELISA and their results expressed as arbitrary units (AU). IgG anticardiolipin antibodies were found in 7 patients (24%), while IgM anticardiolipin antibodies were absent in all. IgG anticardiolipin antibodies were more frequent in IDDM patients than in controls (P<0.005) and group I (in 6 out of 11 patients; 54.5%) than in group II (in 1 out of 18 patients; 5.5%) (P<0.025). In five out of six group I patients with IgG anticardiolipin antibodies, ICA-IgG and/or CF-ICA were also found. No correlation was observed between anticardiolipin and other auto-antibodies, micro-angiopatic complications, and HLA typing.

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Abbreviations

IDDM :

insulin-dependent diabetes mellitus

ICA :

anti-islet cell antibodies

APS :

antiphospholipid syndrome

SLE :

systemic lupus erythematosus

IAA :

anti-insulin antibodies

NOSA :

non organ-specific antibodies

OSA :

organ-specific antibodies

aCL :

anticardiolipin antibodies

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Lorini, R., d'Annunzio, G., Montecucco, C. et al. Anticardiolipin antibodies in children and adolescents with insulin-dependent diabetes mellitus. Eur J Pediatr 154, 105–108 (1995). https://doi.org/10.1007/BF01991910

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