Original articleObjectively Measured Physical Activity and Inflammatory Markers Among US Adults With Diabetes: Implications for Attenuating Disease Progression
Section snippets
Design and Participants
Data from the 2003-2006 National Health and Nutrition Examination Survey (NHANES) was used, with details on the study design found elsewhere.29 The NHANES is conducted by the National Center for Health Statistics, and all procedures for data collection were approved by the National Center for Health Statistics ethics review board. All participants provided written informed consent before data collection. Information from NHANES participants is collected from infants to adults up to 85 years of
Results
Demographic characteristics of the analytic sample are listed in Table 1. Participants were then divided into quartiles on the basis of the level of daily time spent in either light or moderate to vigorous physical activity. Adjusted mean WBC, neutrophil, and CRP values were then compared across the quartiles generated on the basis of physical activity (Table 2). The WBC and neutrophil counts across quartiles were adjusted for age, sex, BMI, race/ethnicity, educational level, CRP level,
Discussion
The purpose of this study was to examine the association between physical activity and WBC, neutrophil, and CRP values among a nationally representative sample of adults with evidence of diabetes. Time spent in either light or moderate to vigorous physical activity was inversely associated with WBC and neutrophil counts, whereas time spent in moderate to vigorous physical activity was inversely associated with CRP levels.
Soinio et al24 reported that among 1045 participants with type 2 diabetes,
Conclusion
Objectively measured physical activity was inversely associated with inflammatory markers, including WBC counts, neutrophil counts, and CRP levels, among this national sample of adults with evidence of diabetes. Strengths of this study include its novelty, use of an objective measure of physical activity, and use of a national sample. However, the cross-sectional design does not allow for causation to be rendered. Future prospective studies are necessary to determine whether interventions
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For editorial comment, see page 907