One-hour post-load plasma glucose levels are associated with elevated liver enzymes
Section snippets
Methods
Subjects in this study consisted of 1000 Caucasian subjects participating to the CAtanzaro MEtabolic RIsk factors Study (CATAMERIS), an observational study for the identification of cardio-metabolic risk factors; the exclusion criteria have been described previously and comprised known history of diabetes mellitus, chronic gastrointestinal diseases or pancreatitis, history of any malignant disease or drug abuse, self-reported alcohol intake of three or more drinks per day and test positivity
Results
Among the 1000 subjects examined, 752 (75.2%) had NGT and 248 (24.8%) had IGT. Subjects with NGT were classified into two groups: 532 subjects with 1-h post-load PG level <155 mg dl−1 (NGT-1h-low) and 220 individuals with 1-h post-load PG level ≥155 mg dl−1 (NGT-1h-high). Table 1 presents the clinical characteristics and laboratory findings of the three study (2 NGT + 1 IGT) groups. Significant differences among these three groups were observed with regard to gender (higher prevalence of men
Discussion
Subjects with NAFLD are characterised by elevated levels of liver biomarkers such as ALT, AST and GGT, and it has been suggested that NAFLD is the most common cause of chronically elevated liver enzymes. Thus, these liver biomarkers, especially ALT, are useful surrogate measures of NAFLD for large-scale studies, and such application is also supported by data that show a significant correlation between liver biomarkers and direct measures of liver fat content [23]. A number of studies have
Acknowledgements
This work was supported, in part, by the Italian Ministry of Health (grant number RF-FSR-2007-631176) to Giorgio Sesti.
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