CommentaryNOD-like and Toll-like receptors or inflammasomes contribute to kidney disease in a canonical and a non-canonical manner
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Upon acceptance of this manuscript Sokolovska et al. reported that NLRP3/ASC/caspase-1 induce NADPH oxidase NOX2 to enhance host defense independent of IL-1β and IL-18, which represents a previously unknown non-canonical function of the NLRP3 inflammasome (Sokolovska A, Becker CE, Ip WK et al. Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. Nat Immunol 2013; 14:543-553).
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