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T-ing up inflammation in fat

Obesity generates a proinflammatory environment in adipose tissue, but the factors that initiate this inflammatory cascade have been unclear. Three studies now show that alterations in the composition of adipose tissue T cells occur early in obesity and shape the relationship between immunity and metabolism (pages 914–920, 921–929 and 930–939).

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Figure 1: Alterations in adipose tissue T (ATT) cells with obesity regulate the inflammatory environment in fat.

Katie Vicari

References

  1. Hotamisligil, G.S. Nature 444, 860–867 (2006).

    Article  CAS  Google Scholar 

  2. Lumeng, C.N., Bodzin, J.L. & Saltiel, A.R. J. Clin. Invest. 117, 175–184 (2007).

    Article  CAS  Google Scholar 

  3. Nishimura, S. et al. Nat. Med. 15, 914–920 (2009).

    Article  CAS  Google Scholar 

  4. Winer, S. et al. Nat. Med. 15, 921–929 (2009).

    Article  CAS  Google Scholar 

  5. Feuerer, M. et al. Nat. Med. 15, 930–939 (2009).

    Article  CAS  Google Scholar 

  6. Gras, S., Kjer-Nielsen, L., Burrows, S.R., McCluskey, J. & Rossjohn, J. Curr. Opin. Immunol. 20, 119–125 (2008).

    Article  CAS  Google Scholar 

  7. Borg, N.A., Kjer-Nielsen, L., McCluskey, J. & Rossjohn, J. Adv. Exp. Med. Biol. 598, 20–34 (2007).

    Article  Google Scholar 

  8. Cao, H. et al. Cell 134, 933–944 (2008).

    Article  CAS  Google Scholar 

  9. Duffaut, C., Galitzky, J., Lafontan, M. & Bouloumie, A. Biochem. Biophys. Res. Commun. 384, 482–485 (2009).

    Article  CAS  Google Scholar 

  10. Sultan, A. et al. Circ. Res. 104, 961–968 (2009).

    Article  CAS  Google Scholar 

  11. Cinti, S. et al. J. Lipid Res. 46, 2347–2355 (2005).

    Article  CAS  Google Scholar 

  12. Rausch, M.E., Weisberg, S., Vardhana, P. & Tortoriello, D.V. Int. J. Obes. (Lond.) 32, 451–463 (2008).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Alan R. Saltiel.

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Lumeng, C., Maillard, I. & Saltiel, A. T-ing up inflammation in fat. Nat Med 15, 846–847 (2009). https://doi.org/10.1038/nm0809-846

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