Chest
Clinical Investigations: INFECTIONEtiology and Outcome of Community-Acquired Pneumonia in Patients With Diabetes Mellitus
Section snippets
Setting and Study Design
For a 5-year period (January 1998 to December 2002), all adult patients in whom community-acquired pneumonia had been diagnosed in the emergency department of the Arnau de Vilanova Hospital in Lleida (Catalonia, Spain) were evaluated for inclusion in a prospective study on epidemiologic, clinical, microbiological, and outcome parameters. This study was examined and approved by the scientific and ethics committees of the institution.
Clinical Evaluation of Patients
On study enrollment, all patients gave a complete clinical
RESULTS
Seven hundred twenty-six patients showing clinical and radiologic findings of community-acquired pneumonia were enrolled in the study; however, 66 patients were subsequently excluded from the study for the following reasons: misdiagnosis at enrollment (n = 59); nosocomial acquisition hospitalization (n = 4); and consent not obtained (n = 3). Thus, 660 patients constituted the final study group. Underlying diseases were found in 324 patients (49%), among which COPD (114 patients), diabetes
DISCUSSION
In this study, we evaluated 106 episodes of community-acquired pneumonia in patients with diabetes mellitus, and the results were compared with those observed in a population of 554 patients with community-acquired pneumonia who did not have diabetes. We found that diabetes was significantly associated with advanced age, the simultaneous presence of other comorbidities, and radiologic evidence of pleural effusion; these episodes were classified as more severe pneumonia, and the rates of
ACKNOWLEDGMENTS
We thank Javier Trujillano, MD, for his contribution to the statistical analysis of the data.
REFERENCES (28)
- et al.
Bacterial pneumonia in hospitalized patients with HIV infection: the pulmonary complications, ICU support, and prognostic factors of hospitalized patients with HIV (PIP) study.
Chest
(2000) - et al.
Host defenses and susceptibility to infection in patients with diabetes mellitus.
Infect Dis Clin North Am
(1995) - et al.
Etiology of community-acquired pneumonia in hospitalized patients: a 3-year prospective study in Japan.
Chest
(1998) - et al.
Evaluation of the PCR method for detection ofStreptococcus pneumoniae DNA in pleural fluid samples.
Chest
(2002) - et al.
A 10-year experience with bacteriology of acute thoracic empyema: emphasis onKlebsiella pneumoniae in patients with diabetes mellitus.
Chest
(2000) - et al.
Pulmonary complications of diabetes mellitus: pneumonia.
Infect Dis Clin North Am
(1995) - et al.
Etiology of community-acquired pneumonia: impact of age, comorbidity, and severity.
Am J Respir Crit Care Med
(1999) - et al.
Study of community-acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines.
Thorax
(2001) - et al.
Bacteremic pneumonia in neutropenic patients with cancer: causes, empirical antibiotic therapy, and outcome.
Arch Intern Med
(1998) - et al.
Community-acquired pneumonia due to Gram-negative bacilli andPseudomonas aeruginosa: incidence, risk, and prognosis.
Arch Intern Med
(2002)
Prognosis and outcomes of patients with community-acquired pneumonia: a meta-analysis.
JAMA
Guidelines for the management of adults with community-acquired pneumonia: diagnosis, assessment of severity, antimicrobial therapy, and prevention.
Am J Respir Crit Care Med
B. Impaired leucocyte functions in diabetic patients.
Diabet Med
Cited by (124)
The mortality and years of life lost for community-acquired pneumonia before and during COVID-19 pandemic in China
2024, The Lancet Regional Health - Western PacificDiabetes and respiratory system including tuberculosis - challenges
2019, Indian Journal of TuberculosisMetagenomic next-generation sequencing for pulmonary infections diagnosis in patients with diabetes
2023, BMC Pulmonary MedicineIXX Conference of the Graduate Committee of the Argentine Diabetes Society Topic: “Diabetes mellitus and non-classical organs” Coordination and general organization of the Conference: Pablo Avila* and Susana Apoloni** Table 1: Lung and diabetes mellitus
2023, Revista de la Sociedad Argentina de Diabetes
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).