Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs

Diabetologia. 2011 Aug;54(8):2206-8. doi: 10.1007/s00125-011-2168-7. Epub 2011 May 21.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adamantane / analogs & derivatives
  • Adamantane / pharmacology
  • Animals
  • Bombesin / pharmacology
  • Dipeptidyl-Peptidase IV Inhibitors / pharmacology*
  • Glucagon-Like Peptide 1 / metabolism*
  • Nitriles / pharmacology
  • Peptide Fragments / pharmacology
  • Portal Vein / drug effects*
  • Portal Vein / metabolism*
  • Pyrrolidines / pharmacology
  • Swine
  • Vildagliptin

Substances

  • Dipeptidyl-Peptidase IV Inhibitors
  • Nitriles
  • Peptide Fragments
  • Pyrrolidines
  • neuromedin C
  • Glucagon-Like Peptide 1
  • Vildagliptin
  • Adamantane
  • Bombesin