[HTML][HTML] Covering chemical diversity of genetically-modified tomatoes using metabolomics for objective substantial equivalence assessment

M Kusano, H Redestig, T Hirai, A Oikawa, F Matsuda… - PLoS …, 2011 - journals.plos.org
As metabolomics can provide a biochemical snapshot of an organism's phenotype it is a
promising approach for charting the unintended effects of genetic modification. A critical …

Genetically stable expression of functional miraculin, a new type of alternative sweetener, in transgenic tomato plants

HJ Sun, H Kataoka, M Yano… - Plant biotechnology …, 2007 - Wiley Online Library
Miraculin is a taste‐modifying protein isolated from the red berries of Richadella dulcifica, a
shrub native to West Africa. Miraculin by itself is not sweet, but it is able to turn a sour taste …

[HTML][HTML] Social contact impacts physical activity and sedentary behavior among older adults in Japan due to COVID-19

N Otaki, M Yokoro, M Yano, T Imamura, M Akita… - BMC geriatrics, 2022 - Springer
Background The coronavirus disease 2019 (COVID-19) has adversely affected social
contact and physical activity. This study investigated the correlation between physical …

[HTML][HTML] Low dietary variety is associated with incident frailty in older adults during the coronavirus disease 2019 pandemic: a prospective cohort study in Japan

M Yokoro, N Otaki, M Yano, T Imamura, N Tanino… - Nutrients, 2023 - mdpi.com
Background: Stagnation of social activity due to the COVID-19 pandemic probably reduces
motivation to maintain a healthy diet. It is important to report on the dietary changes …

[HTML][HTML] Effects of 4G-beta-D-Galactosylsucrose in patients with depression: A randomized, double-blinded, placebo-controlled, parallel-group comparative study

S Tarutani, M Omori, Y Ido, M Yano, T Komatsu… - Journal of psychiatric …, 2022 - Elsevier
Advances in genetic research on microbiome have led to several trials on the effectiveness
of synbiotics or probiotics in patients with depression; however, none have evaluated the …

Relationship between dietary variety and frailty in older Japanese women during the period of restriction on outings due to COVID-19

N Otaki, M Yano, M Yokoro, N Tanino… - The Journals of …, 2021 - academic.oup.com
Objectives To investigate the relationship between diet and frailty in community-dwelling
older adults during the period of restriction on outings due to novel coronavirus disease …

Transgenic strawberry expressing the taste-modifying protein miraculin

T Sugaya, M Yano, HJ Sun, T Hirai, H Ezura - Plant biotechnology, 2008 - jstage.jst.go.jp
The gene encoding the taste-modifying protein miraculin was introduced under the control of
the 35S or El2 promoter into strawberry (Fragaria x ananassa) by Agrobacterium-mediated …

Miraculin, a taste-modifying protein is secreted into intercellular spaces in plant cells

T Hirai, M Sato, K Toyooka, HJ Sun, M Yano… - Journal of plant …, 2010 - Elsevier
A taste-modifying protein, miraculin, is highly accumulated in ripe fruit of miracle fruit
(Richadella dulcifica) and the content can reach up to 10% of the total soluble protein in …

Tomato is a suitable material for producing recombinant miraculin protein in genetically stable manner

M Yano, T Hirai, K Kato, K Hiwasa-Tanase, N Fukuda… - Plant science, 2010 - Elsevier
Miraculin is a taste-modifying protein that turns sour tastes into sweet ones. We previously
generated transgenic tomato plants that constitutively expressed miraculin. To study the …

[HTML][HTML] Association between asymmetric dimethylarginine and sarcopenia in community-dwelling older women

M Yokoro, N Otaki, M Yano, T Imamura, N Tanino… - Scientific Reports, 2023 - nature.com
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelium nitric oxide
synthesis and causes endothelial dysfunction that may be related to sarcopenia. However …