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The effect of slow spaced eating on hunger and satiety in overweight and obese patients with type 2 diabetes mellitus
  1. Theodoros Angelopoulos1,
  2. Alexander Kokkinos1,
  3. Christos Liaskos1,
  4. Nicholas Tentolouris1,
  5. Kleopatra Alexiadou1,
  6. Alexander Dimitri Miras2,
  7. Iordanis Mourouzis3,
  8. Despoina Perrea4,
  9. Constantinos Pantos3,
  10. Nicholas Katsilambros1,
  11. Stephen R Bloom2,
  12. Carel Wynard le Roux2
  1. 1First Department of Propaedeutic Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece
  2. 2Department of Metabolic Medicine, Hammersmith Hospital, Imperial College, London, UK
  3. 3Department of Pharmacology, Athens University Medical School, Athens, Greece
  4. 4Laboratory of Experimental Surgery and Surgical Research “N.S. Christeas”, Athens University Medical School, Athens, Greece
  1. Correspondence to Dr Alexander Kokkinos; rjd{at}otenet.gr

Abstract

Background Slow spaced eating is associated with improved satiety and gut hormone responses in normal-weight participants. This crossover study compared the effect of slow and rapid eating patterns on hunger, fullness, glucose, insulin, and the appetite-related gut hormones peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and ghrelin in overweight and obese participants with type 2 diabetes mellitus (T2DM).

Methods 20 overweight and obese participants with T2DM on metformin were recruited. A test meal of 300 mL ice-cream was consumed in random order in two different sessions by each participant; meal duration was 5 or 30 min. Fullness and hunger as assessed by visual analog scales (VAS), and glucose, insulin, PYY, GLP-1, and ghrelin were measured at baseline and at 30 min intervals after meal termination for 3 h.

Results Fullness VAS ratings were significantly higher at the 90’, 120’, 150’, and 180’ time points and hunger ratings were lower at 90’, 150’, and 180’ for the 30 min meal. The area under the curve (AUC) for fullness was higher after the 30 min meal than after the 5 min meal (11 943.7±541.2 vs 10 901.0±568.8 mm min, p=0.003) whereas the hunger AUC was lower (4442.9±328 vs 4966.7±347.5 mm min, p=0.012). There were no differences in glucose, insulin, PYY, GLP-1, and ghrelin responses.

Conclusions Slow spaced eating increased fullness and decreased hunger ratings in overweight and obese participants with T2DM, without the improvement in gut hormone responses found in normal-weight participants. Slow spaced eating may be a useful prevention strategy, but might also help curb food intake in those already suffering from obesity and diabetes.

  • Gut Peptides
  • Eating Behavior(s)
  • Satiety

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

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