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Impact of increased visceral adiposity with normal weight on the progression of arterial stiffness in Japanese patients with type 2 diabetes
  1. Ryotaro Bouchi1,
  2. Isao Minami1,
  3. Norihiko Ohara1,
  4. Yujiro Nakano1,
  5. Rie Nishitani1,
  6. Masanori Murakami1,
  7. Takato Takeuchi1,
  8. Momoko Akihisa1,
  9. Tatsuya Fukuda1,
  10. Masamichi Fujita1,
  11. Takanobu Yoshimoto1,
  12. Yoshihiro Ogawa1,2
  1. 1Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
  2. 2Japan Science and Technology Agency, CREST, Tokyo, Japan
  1. Correspondence to Professor Yoshihiro Ogawa; ogawa.mem{at}


Objective Normal-weight abdominal obesity has been reported to be associated with poor mortality. We aimed to investigate the impact of increased visceral adiposity with normal weight (OB(−)VA(+)) on the progression of arterial stiffness in patients with type 2 diabetes.

Methods This was a cross-sectional study of 414 patients with type 2 diabetes (mean age 64±12 years; 40.3% female). Visceral fat area (VFA, cm2) was measured by a dual bioelectrical impedance analyzer. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV, cm/s). Patients were divided into four groups by VFA and body mass index (BMI, kg/m2) as the following: BMI<25 kg/m2 and VFA<100 cm2 (obesity (OB)(−)visceral adiposity (VA)(−)), BMI≥25 kg/m2 and VFA<100 cm2 (OB(+)VA(−)), BMI<25 kg/m2 and VFA≥100 cm2 (OB(−)VA(+)), and BMI≥25 kg/m2 and VFA≥100 cm2 (OB(+)VA(+)). Multivariate linear regression analysis was done to determine the impact of OB(−)VA(+) on arterial stiffness.

Results Among the patients, 7.2% were OB(−)VA(+) with higher baPWV levels (1956±444 cm/s) than those with OB(+)VA(−) (1671±416 cm/s, p=0.014), those with OB(+)VA(+) (1744±317 cm/s, p=0.048), and those with OB(−)VA(−) (1620±397 cm/s, p=0.024). In multivariate linear regression analysis, OB(−)VA(+) remained independently associated with baPWV (standardized β 0.184, p=0.001).

Conclusions This study provides evidence for the burden of arterial stiffness in OB(−)VA(+) patients with type 2 diabetes; therefore, evaluation of visceral adiposity is of clinical relevance for the better management of non-obese individuals as well as obese populations.

  • Atherosclerosis
  • Body Mass Index
  • Visceral Obesity

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