Article Text

Vitamin D for the treatment of painful diabetic neuropathy
  1. Abdul Basit1,2,
  2. Khalid Abdul Basit1,
  3. Asher Fawwad1,2,
  4. Fariha Shaheen1,
  5. Nimra Fatima1,
  6. Ioannis N Petropoulos3,
  7. Uazman Alam4,
  8. Rayaz A Malik3,4
  1. 1Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan
  2. 2Baqai Medical University, Karachi, Pakistan
  3. 3Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar
  4. 4Centre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester and the Manchester Royal Infirmary, Central Manchester Hospital Foundation Trust, Manchester, UK
  1. Correspondence to Professor Rayaz A Malik; rayaz.a.malik{at}


Objective To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.

Methods A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.

Results 143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).

Conclusions Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.

Trial registration number BIDE-12/2014.

  • Vitamin D
  • Pain
  • Neuropathy Complications
  • Neuropathy and Clinical Diabetes

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