Article Text

Download PDFPDF

Plasma glucose and insulin response to two oral nutrition supplements in adults with type 2 diabetes mellitus
  1. Maureen B Huhmann1,
  2. Kristen N Smith1,
  3. Sherwyn L Schwartz2,
  4. Stacie K Haller2,
  5. Sarah Irvin3,
  6. Sarah S Cohen3
  1. 1Department of Clinical Sciences, Nestle Health Science, Florham Park, New Jersey, USA
  2. 2Diabetes & Glandular Disease Clinic, San Antonio, Texas, USA
  3. 3EpidStat Institute, Ann Arbor, Michigan, USA
  1. Correspondence to Dr Maureen B Huhmann; Maureen.huhmann{at}


Objective The purpose of this clinical trial was to compare the glucose usage of two oral nutritional supplement (ONS) products and to assess whether a diabetes-specific formulation provides improved glucose stabilization and management compared with a standard formula.

Research design and methods A total of 12 subjects with type 2 diabetes (7 males and 5 females) completed a randomized, cross-over design trial. Each subject consumed isocaloric amounts of either the standard ONS or the diabetes-specific formula ONS on different dates, 1 week apart. Glucose and insulin measures were recorded at baseline, and 10, 20, 30, 60, 90, 120, 150, 180, 210 and 240 min after the beverage was consumed and then used to calculate area under the curve (AUC) for each subject.

Results The mean glucose AUC was lower in the diabetes-specific ONS group than in the standard group (p<0.0001), but there was not a significant difference observed for mean insulin AUC (p=0.068). A sensitivity analysis of the mean insulin AUC measures was performed by removing a potential outlier from the analysis, and this resulted in a significant difference between the groups (p=0.012). First-phase insulin measures and an insulinogenic index calculated for the beverages showed no significant differences.

Conclusions On the basis of the results of this trial of 12 subjects, the diabetes-specific ONS appears to provide better glucose maintenance in persons with type 2 diabetes when compared to the standard formula ONS.

Trial registration number NCT02612675.

  • Nutrition
  • Nutritional Intervention

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.