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Insulin resistance of protein anabolism accompanies that of glucose metabolism in lean, glucose-tolerant offspring of persons with type 2 diabetes
  1. Sergio A Burgos1,2,
  2. Vikram Chandurkar3,
  3. Michael A Tsoukas1,
  4. Stéphanie Chevalier1,
  5. José A Morais1,
  6. Marie Lamarche1,
  7. Errol B Marliss1
  1. 1Crabtree Nutrition Laboratories, Division of Endocrinology and Metabolism, Department of Medicine, McGill University Health Centre Research Institute, Montreal, Quebec, Canada
  2. 2Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Sainte-Anne-de-Bellevue, Quebec, Canada
  3. 3Division of Endocrinology, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada
  1. Correspondence to Dr Errol B Marliss; errol.marliss{at}mcgill.ca

Footnotes

  • Contributors SAB, VC, MAT, SC, and EBM designed the experimental protocol. SAB, VC, MAT, SC, JAM, ML, and EBM recruited and screened participants and conducted the clamp experiment. SAB, SC, ML, and EBM performed and/or supervised the laboratory analyses and analyzed data. SAB, SC, and EBM wrote the manuscript. All authors approved the manuscript.

  • Funding This work was supported by a grant from Canadian Institutes of Health Research to EBM (MOP-62889).

  • Competing interests None declared.

  • Ethics approval Ethics Review Board of the McGill University Health Centre.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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Footnotes

  • Contributors SAB, VC, MAT, SC, and EBM designed the experimental protocol. SAB, VC, MAT, SC, JAM, ML, and EBM recruited and screened participants and conducted the clamp experiment. SAB, SC, ML, and EBM performed and/or supervised the laboratory analyses and analyzed data. SAB, SC, and EBM wrote the manuscript. All authors approved the manuscript.

  • Funding This work was supported by a grant from Canadian Institutes of Health Research to EBM (MOP-62889).

  • Competing interests None declared.

  • Ethics approval Ethics Review Board of the McGill University Health Centre.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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