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Adverse effect of long work hours on incident diabetes in 7065 Ontario workers followed for 12 years
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  • Published on:
    Estrogens and other uncovered associations with diabetes and cardiovascular diseases among female workers
    • Jiamei Wang, Head Nurse Department of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University
    • Other Contributors:
      • Fei Peng, Head Nurse
      • Zonggui Wu, Cardiologist
      • Chun Liang, Cardiologist

    To the Editor

    We read with great interest the article by Gilbert-Ouimet M et al1 recently published in your journal. Such study showed an interesting result that only increased risk of incidence of diabetes occurring among female workers working 45 hours or more per week, and suggested that modification of such risk factors would be helpful to improve prevention strategies and orient policymaking by following up 7065 workers over a 12-year period in Ontario, Canada.
    However, we have some concerns. Firstly, in order to find out the potential relationship between long work hours and the incidence of diabetes, several other independent variables were considered in the analysis process such as sociodemographic and health-related covariates, but the information of menopause and menopausal hormone therapy (MHT) among women was not added. Strong association with increased risk of cardiovascular diseases had been confirmed in several studies and data from large randomized-controlled trials have shown that the decrease of incidence of T2D in women could be achieved by MHT with conjugated estrogens 2,3 . Although the clinical evidence still not be sufficient to recommend the use of hormones for prevention of diabetes among women especially with early menopause or premature ovarian insufficiency4, such detail might be helpful to uncover the neglected association between menopause and increased risk of diabetes.
    Secondly, compared with the increased risk...

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    Conflict of Interest:
    None declared.