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Relationship between baseline physical activity assessed by pedometer count and new-onset diabetes in the NAVIGATOR trial
  1. William E Kraus1,
  2. Thomas Yates2,
  3. Jaakko Tuomilehto3,4,
  4. Jie-Lena Sun1,
  5. Laine Thomas1,
  6. John J V McMurray5,
  7. M Angelyn Bethel6,
  8. Rury R Holman6
  1. 1 Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
  2. 2 Diabetes Research Centre, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
  3. 3 Professor of Vascular Prevention, Danube-University Krems, Krems an der Donau, Austria
  4. 4 Professor Emeritus, University of Helsinki, Helsinki, Finland
  5. 5 British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland
  6. 6 Diabetes Trials Unit, University of Oxford, Oxford, UK
  1. Correspondence to Dr William E Kraus; william.kraus{at}duke.edu

Footnotes

  • Contributors WEK wrote the manuscript and researched the data. TY, JT, J-LS, LT, JJVM, MAB, SMH, and RRH reviewed the manuscript critically and contributed to the content. J-LS and LT performed the statistical analysis.

  • Funding The NAVIGATOR study was supported by Novartis, Inc. TY is supported by the NIHR Diet, Lifestyle and Physical Activity Biomedical Research Unit, Leicester, UK. WEK was supported by NIDDK/NIA grant DK081559 for purposes of this project.

  • Competing interests TY: Research support from the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre and the NIHR Collaboration for Leadership in Applied Health Research and Care, East Midlands. MAB: Research support from Merck Serono; attended advisory boards with Boehringer Ingelheim, AstraZeneca, and Novo Nordisk. Her department has received research funding from Merck, Amylin, Lilly, and BMS. RRH: Research support from Amylin, Bayer, Merck, and Novartis; attended advisory boards with Amylin, Lilly, Merck, Novartis, and Novo Nordisk; and given lectures supported by Bayer, Lilly, Merck, and Novo Nordisk.

  • Patient consent Not required.

  • Ethics approval Duke University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The data contained in this manuscript are held at the Duke Clinical Research Institute.

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Footnotes

  • Contributors WEK wrote the manuscript and researched the data. TY, JT, J-LS, LT, JJVM, MAB, SMH, and RRH reviewed the manuscript critically and contributed to the content. J-LS and LT performed the statistical analysis.

  • Funding The NAVIGATOR study was supported by Novartis, Inc. TY is supported by the NIHR Diet, Lifestyle and Physical Activity Biomedical Research Unit, Leicester, UK. WEK was supported by NIDDK/NIA grant DK081559 for purposes of this project.

  • Competing interests TY: Research support from the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre and the NIHR Collaboration for Leadership in Applied Health Research and Care, East Midlands. MAB: Research support from Merck Serono; attended advisory boards with Boehringer Ingelheim, AstraZeneca, and Novo Nordisk. Her department has received research funding from Merck, Amylin, Lilly, and BMS. RRH: Research support from Amylin, Bayer, Merck, and Novartis; attended advisory boards with Amylin, Lilly, Merck, Novartis, and Novo Nordisk; and given lectures supported by Bayer, Lilly, Merck, and Novo Nordisk.

  • Patient consent Not required.

  • Ethics approval Duke University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The data contained in this manuscript are held at the Duke Clinical Research Institute.

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