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Elevated serum adiponectin and tumor necrosis factor-α and decreased transthyretin in Japanese elderly women with low grip strength and preserved muscle mass and insulin sensitivity
  1. Mika Takeuchi1,
  2. Ayaka Tsuboi2,3,
  3. Satomi Minato2,4,
  4. Megumu Yano2,
  5. Kaori Kitaoka2,5,
  6. Miki Kurata1,5,
  7. Tsutomu Kazumi2,6,
  8. Keisuke Fukuo1,2
  1. 1 Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women’s University, Nishinomiya, Japan
  2. 2 Research Institute for Nutrition Sciences, Mukogawa Women’s University, Nishinomiya, Japan
  3. 3 Department of Nutrition, Osaka City Juso Hospital, Osaka, Japan
  4. 4 Graduate School of Human Science and Environment, University of Hyogo, Himeji, Japan
  5. 5 Department of Nutritional Sciences for Well-being, Faculty of Health Sciences for Welfare, Kansai University of Welfare Sciences, Kashiwara, Japan
  6. 6 Diabetes Division, Department of Medicine, Kohnan Kakogawa Hospital, Kakogawa, Japan
  1. Correspondence to Dr Tsutomu Kazumi; kazumi{at}


Objective To determine if adiponectin levels are associated with low grip strength among the elderly independently of insulin resistance and inflammation.

Research design and methods Cross-sectional associations were analyzed by logistic regression between low grip strength and body composition, elevated serum adiponectin (≥20 mg/L), and biomarkers of nutritious stasis, insulin resistance and inflammation in 179 community-living Japanese women. Sarcopenia was evaluated using the Asian criteria.

Results No women had sarcopenia. In bivariate analyses, low grip strength (n=68) was positively associated with age, log tumor necrosis factor-α (TNF-α) and hyperadiponectinemia (n=37) and inversely with body weight, height, skeletal muscle mass, serum albumin, transthyretin (TTR), fat mass, serum zinc and hemoglobin (all p<0.01). In a fully adjusted model, TTR (0.90: 0.83–0.98, p=0.01) in addition to age (p=0.007), height (p=0.004) and skeletal muscle mass (p=0.008) emerged as independent determinants of low grip strength. When TTR was removed from the full model, TNF-α was associated with low grip strength (7.7; 1.3–45.8, p=0.02). Mean waist circumference and high-density lipoprotein cholesterol did not differ between women with and without low grip strength and were within the respective normal range. Women with hyperadiponectinemia had higher percentage of women with low grip strength and lower grip strength (both p<0.01).

Conclusions Hyperadiponectinemia and elevated TNF-α in addition to decreased TTR, a biomarker of age-related catabolic states, were found in community-living Japanese elderly women with low grip strength and preserved muscle mass and insulin sensitivity.

  • elderly women
  • grip strength
  • muscle mass
  • adiponectin
  • transthyretin
  • insulin resistance
  • inflammation

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  • Author contribution MT, AT, SM, MY, KK and MK collected and analyzed the data. TK wrote the manuscript, and KF reviewed and edited it. All authors approved the final version of the manuscript to be published. TK supervised the study, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Parental/guardian consent obtained.

  • Ethics approval The Ethics Committee of Mukogawa Women’s University (No. 11-7).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The ethics committee of the university does not allow us to open data except for a manuscript.

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