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Obesity Studies
Original research
Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet

Authors

  • Liang Xu Department of Cell Metabolism and Nutrition, Advanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan Key Laboratory of Laboratory Medicine, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, China PubMed articlesGoogle scholar articles
  • Naoto Nagata Department of Cell Metabolism and Nutrition, Advanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan PubMed articlesGoogle scholar articles
  • Guanliang Chen Department of Cell Metabolism and Nutrition, Advanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan PubMed articlesGoogle scholar articles
  • Mayumi Nagashimada Department of Cell Metabolism and Nutrition, Advanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan PubMed articlesGoogle scholar articles
  • Fen Zhuge Department of Cell Metabolism and Nutrition, Advanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan PubMed articlesGoogle scholar articles
  • Yinhua Ni Department of Cell Metabolism and Nutrition, Advanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan PubMed articlesGoogle scholar articles
  • Yuriko Sakai Department of Cell Metabolism and Nutrition, Advanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan PubMed articlesGoogle scholar articles
  • Shuichi Kaneko Department of Cell Metabolism and Nutrition, Advanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan PubMed articlesGoogle scholar articles
  • Tsuguhito Ota Department of Cell Metabolism and Nutrition, Advanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Tsuguhito Ota; ota{at}asahikawa-med.ac.jp
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Citation

Xu L, Nagata N, Chen G, et al
Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet
BMJ Open Diabetes Research and Care 2019;7:e000783. doi: 10.1136/bmjdrc-2019-000783

Publication history

  • Received August 1, 2019
  • Revised September 15, 2019
  • Accepted September 30, 2019
  • First published October 25, 2019.
Online issue publication 
May 15, 2023

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.