You are here

Article Text

Article menu
XML
Epidemiology/Health services research
Association of periodontal pocket area with type 2 diabetes and obesity: a cross-sectional study
  1. Kohei Takeda1,
  2. Koji Mizutani1,
  3. Isao Minami2,3,
  4. Daisuke Kido1,
  5. Risako Mikami1,
  6. Kuniha Konuma1,
  7. Natsumi Saito1,
  8. Hiromi Kominato1,
  9. Shu Takemura1,
  10. Keita Nakagawa1,
  11. Yuichi Izumi1,4,
  12. Yoshihiro Ogawa5,
  13. Takanori Iwata1
  1. 1Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
  2. 2Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
  3. 3Department of Endocrinology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan
  4. 4Oral Care Perio Center, Southern Tohoku Research Institute for Neuroscience Southern Tohoku General Hospital, Fukushima, Japan
  5. 5Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  1. Correspondence to Dr Koji Mizutani; mizuperi{at}tmd.ac.jp

Abstract

Introduction The aim was to investigate the relationship of full-mouth inflammatory parameters of periodontal disease with diabetes and obesity.

Research design and methods This cross-sectional study conducted diabetes-related examinations and calculated periodontal inflamed and epithelial surface area (PISA and PESA) of 71 Japanese patients with type 2 diabetes. Multiple linear regression analyses were performed to evaluate associations between PISA or PESA and diabetes and obesity parameters.

Results Median value of body mass index (BMI), hemoglobin A1c (HbA1c) level, fasting plasma glucose (FPG) level, and visceral fat area (VFA) were 25.7 kg/m2, 9.1%, 151 mg/L, and 93.3 cm2, respectively. PISA and PESA were significantly associated with HbA1c after adjusting for age, sex, BMI, smoking status, and full-mouth plaque control level (PISA: coefficient=38.1, 95% CI 8.85 to 67.29, p=0.001; PESA: coefficient=66.89, 95% CI 21.44 to 112.34, p=0.005). PISA was also significantly associated with the highest FPG tertile (>175 mg/dL) after adjusting for confounders (coefficient=167.0, 95% CI 48.60 to 285.4, p=0.006). PISA and PESA were not significantly associated with BMI or VFA.

Conclusion PISA was associated with FPG and HbA1c, but not with obesity parameters, independent from confounders such as full-mouth plaque control level in patients with type 2 diabetes.

  • diabetes complications
  • obesity
  • periodontal diseases
  • inflammation

Data availability statement

No data are available. This trial was registered in the University Hospital Medical Information Network (UMIN; https://www.umin.ac.jp/), clinical trial number: UMIN000040218.

http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjdrc-2021-002139

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Data availability statement

    No data are available. This trial was registered in the University Hospital Medical Information Network (UMIN; https://www.umin.ac.jp/), clinical trial number: UMIN000040218.

    View Full Text

    Supplementary materials

    Footnotes

    • Contributors KT, KM, and RM participated in study design, statistical analysis, and manuscript preparation and review. IM participated in study design, study logistics, data analysis, and manuscript preparation and review. DK and KK participated in collection of study data. NS and HK participated in manuscript review. ST and KN participated in data analysis. YI, YO, and TI participated in study design, study logistics, and manuscript review.

    • Funding This study was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (16K20666 and 20K18525).

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.