@article {Kishimotoe000137, author = {Ichiro Kishimoto and Hisashi Makino and Yoko Ohata and Tamiko Tamanaha and Mayu Tochiya and Toshihisa Anzai and Kengo Kusano and Teruo Noguchi and Satoshi Yasuda and Hisao Ogawa}, title = {Intensity of statin therapy and new hospitalizations for heart failure in patients with type 2 diabetes}, volume = {3}, number = {1}, elocation-id = {e000137}, year = {2015}, doi = {10.1136/bmjdrc-2015-000137}, publisher = {BMJ Specialist Journals}, abstract = {Objective To examine a relationship between statin intensity and heart failure (HF) incidence in diabetes.Research design and methods We performed a retrospective cohort study of patients with type 2 diabetes (n=600; age, 66.3 years; men, 68\%). Patients were categorized into three groups by baseline statin treatments{\textemdash}moderate-intensity, low-intensity, or no statin{\textemdash}and the independent association between the statin category and HF hospitalization during follow-up was examined.Results Over the course of the median 6-year follow-up, 17.7\% of the patients were hospitalized for HF. Cox regression analysis revealed a significant association between the baseline statin category and HF incidence (p=0.002), independently of age, sex, hypertension, B-type natriuretic peptide, glycated hemoglobin, estimated glomerular filtration rate, and low-density lipoprotein (LDL) cholesterol levels. The moderate-intensity statin group had a significantly lower risk for HF than the low-intensity statin group with an adjusted HR of 0.31 (95\% CI 0.13 to 0.65, p=0.0014). Interestingly, among patients with prevalent coronary artery diseases (CAD) and with baseline LDL controlled to less than 100 mg/dL, the frequency of HF was still significantly lower in the moderate-intensity group than in the low-intensity group or the no statin group. The effect of baseline statin category on HF was independent of incident CAD events during follow-up.Conclusions In type 2 diabetes, moderate-intensity statins, in comparison to low-intensity or no statin, were associated with lower HF incidence independently of LDL levels or of CAD events.}, URL = {https://drc.bmj.com/content/3/1/e000137}, eprint = {https://drc.bmj.com/content/3/1/e000137.full.pdf}, journal = {BMJ Open Diabetes Research and Care} }