@article {Basite000148, author = {Abdul Basit and Khalid Abdul Basit and Asher Fawwad and Fariha Shaheen and Nimra Fatima and Ioannis N Petropoulos and Uazman Alam and Rayaz A Malik}, title = {Vitamin D for the treatment of painful diabetic neuropathy}, volume = {4}, number = {1}, elocation-id = {e000148}, year = {2016}, doi = {10.1136/bmjdrc-2015-000148}, publisher = {BMJ Specialist Journals}, abstract = {Objective To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.Methods A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.Results 143 participants with predominantly type 2 diabetes, aged 52.31{\textpm}11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0{\textpm}1.8), total McGill pain score (21.2{\textpm}14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1{\textpm}0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7{\textpm}23.3 ng/mL and 58 (40.5\%) patients showed evidence of vitamin D deficiency (25(OH)D\<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2{\textpm}10.2 ng/mL, p\<0.0001) and a reduction in positive symptoms on the DN4 (p\<0.0001), total pain score (p\<0.0001), and SFMPQ (p\<0.0001).Conclusions Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.Trial registration number BIDE-12/2014.}, URL = {https://drc.bmj.com/content/4/1/e000148}, eprint = {https://drc.bmj.com/content/4/1/e000148.full.pdf}, journal = {BMJ Open Diabetes Research and Care} }