PT  - JOURNAL ARTICLE
AU  - Abdul Basit
AU  - Khalid Abdul Basit
AU  - Asher Fawwad
AU  - Fariha Shaheen
AU  - Nimra Fatima
AU  - Ioannis N Petropoulos
AU  - Uazman Alam
AU  - Rayaz A Malik
TI  - Vitamin D for the treatment of painful diabetic neuropathy
AID  - 10.1136/bmjdrc-2015-000148
DP  - 2016 Feb 01
TA  - BMJ Open Diabetes Research & Care
PG  - e000148
VI  - 4
IP  - 1
4099  - http://drc.bmj.com/content/4/1/e000148.short
4100  - http://drc.bmj.com/content/4/1/e000148.full
SO  - BMJ Open Diab Res Care2016 Feb 01; 4
AB  - Objective To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.Methods A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.Results 143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).Conclusions Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.Trial registration number BIDE-12/2014.