RT Journal Article
SR Electronic
T1 Peripheral sensory neuropathy is associated with altered postocclusive reactive hyperemia in the diabetic foot
JF BMJ Open Diabetes Research & Care
JO BMJ Open Diab Res Care
FD American Diabetes Association
SP e000235
DO 10.1136/bmjdrc-2016-000235
VO 4
IS 1
A1 Alex L Barwick
A1 John W Tessier
A1 Xanne Janse de Jonge
A1 James R Ivers
A1 Vivienne H Chuter
YR 2016
UL http://drc.bmj.com/content/4/1/e000235.abstract
AB Objective This study examined whether the presence of peripheral sensory neuropathy or cardiac autonomic deficits is associated with postocclusive reactive hyperemia (reflective of microvascular function) in the diabetic foot.Research design and methods 99 participants with type 2 diabetes were recruited into this cross-sectional study. The presence of peripheral sensory neuropathy was determined with standard clinical tests and cardiac autonomic function was assessed with heart rate variation testing. Postocclusive reactive hyperemia was measured with laser Doppler in the hallux. Multiple hierarchical regression was performed to examine relationships between neuropathy and the peak perfusion following occlusion and the time to reach this peak.Results Peripheral sensory neuropathy predicted 22% of the variance in time to peak following occlusion (p<0.05), being associated with a slower time to peak but was not associated with the magnitude of the peak. Heart rate variation was not associated with the postocclusive reactive hyperemia response.Conclusions This study found an association between the presence of peripheral sensory neuropathy in people with diabetes and altered microvascular reactivity in the lower limb.