PT - JOURNAL ARTICLE AU - James C Barton AU - J Clayborn Barton AU - Paul C Adams AU - Ronald T Acton TI - Undiagnosed diabetes and impaired fasting glucose in <em>HFE</em> C282Y homozygotes and <em>HFE</em> wild-type controls in the HEIRS Study AID - 10.1136/bmjdrc-2016-000278 DP - 2016 Dec 01 TA - BMJ Open Diabetes Research &amp; Care PG - e000278 VI - 4 IP - 1 4099 - http://drc.bmj.com/content/4/1/e000278.short 4100 - http://drc.bmj.com/content/4/1/e000278.full SO - BMJ Open Diab Res Care2016 Dec 01; 4 AB - Objective To determine prevalences and predictors of undiagnosed diabetes mellitus (UDM) and impaired fasting glucose (IFG) in non-Hispanic whites with HFE p.C282Y homozygosity and controls without common HFE mutations identified in population screening.Research design and methods We analyzed these observations in a postscreening examination: age; sex; body mass index; systolic/diastolic blood pressure; metacarpophalangeal joint hypertrophy; hepatomegaly; blood neutrophils; alanine and aspartate aminotransferase; elevated C reactive protein; transferrin saturation; serum ferritin; and Field Center.Results There were 223 p.C282Y homozygotes and 449 controls without diagnosed diabetes (43.9% men). Mean age of p.C282Y homozygotes was 52±13 years (controls 57±14 years; p&lt;0.0001). Mean transferrin saturation in p.C282Y homozygotes was 67±26% (controls 34±14%; p&lt;0.0001). Mean serum ferritin in p.C282Y homozygotes was 607 pmol/L (95% CI 497 to 517; controls 274 pmol/L (247 to 301); p&lt;0.0001). Overall prevalences of UDM (4.0% vs 4.2%) and IFG (23.8% vs 25.6%) did not differ significantly between p.C282Y homozygotes and wt/wt controls, respectively. In logistic regressions, male sex, body mass index, and alanine aminotransferase were significantly associated with UDM. ORs were 2.7 (1.2 to 2.8); 1.0 (1.0 to 1.1); and 1.0 (1.0 to 1.0), respectively. Age, male sex, and body mass index were significantly associated with IFG. ORs were 1.0 (1.0 to 1.1); 2.8 (1.9 to 4.2); and 1.0 (1.0 to 1.1), respectively.Conclusions Prevalences of UDM and IFG were similar in p.C282Y homozygotes and controls in a postpopulation screening examination. Male sex was the strongest predictor of UDM and IFG.