RT Journal Article
SR Electronic
T1 Impact of weight loss on waist circumference and the components of the metabolic syndrome
JF BMJ Open Diabetes Research & Care
JO BMJ Open Diab Res Care
FD American Diabetes Association
SP e000341
DO 10.1136/bmjdrc-2016-000341
VO 5
IS 1
A1 Amy E Rothberg
A1 Laura N McEwen
A1 Andrew T Kraftson
A1 Nevin Ajluni
A1 Christine E Fowler
A1 Catherine K Nay
A1 Nicole M Miller
A1 Charles F Burant
A1 William H Herman
YR 2017
UL http://drc.bmj.com/content/5/1/e000341.abstract
AB Objective Central adiposity is a component of the metabolic syndrome (MetS). Little is known about the impact of medical weight loss and decreased waist circumference (WC) on the MetS. Our objective was to assess the impact of changes in WC on blood pressure, lipids and glycemia.Research design and methods We studied 430 obese patients enrolled in a 2-year, intensive, behavioral, weight management program. We report results for participants who completed 6-month and 2-year follow-up.Results Participants were 49±9 years of age (mean±SD), 56% were women and 85% were white. Baseline body mass index (BMI) was 41±6 kg/m2 and baseline WC was 120±14 cm. At 6 months, BMI decreased by 6±3 kg/m2 and WC by 14±9 cm. Relative change in WC was defined as the 6-month or 2-year WC minus the baseline WC divided by the baseline WC. Systolic blood pressure decreased by 8 mm Hg for the tertile of participants with the largest relative decrease in WC and by 2 mm Hg for those with the smallest relative decrease in WC (p=0.025). Similar patterns of improvement were observed in total cholesterol (−29 vs −12 mg/dL, p=0.017), low-density lipoprotein-cholesterol (−19 vs −4 mg/dL, p=0.033), and glycated hemoglobin (−1.2 vs −0.3%, p=0.006). At 2 years, BMI decreased by 5±4 kg/m2 and WC by 11±11 cm and similar patterns of improvements were seen in components of the MetS. At both 6 months and 2 years, larger relative decreases in WC were associated with greater improvements in lipids and glycemia independent of sex.Conclusions In obese people, greater relative decreases in WC with medical weight loss are associated with greater improvements in components of the MetS independent of sex.