RT Journal Article SR Electronic T1 Diabetes incidence and glucose intolerance prevalence increase with higher outdoor temperature JF BMJ Open Diabetes Research & Care JO BMJ Open Diab Res Care FD American Diabetes Association SP e000317 DO 10.1136/bmjdrc-2016-000317 VO 5 IS 1 A1 Blauw, Lisanne L A1 Aziz, N Ahmad A1 Tannemaat, Martijn R A1 Blauw, C Alexander A1 de Craen, Anton J A1 Pijl, Hanno A1 Rensen, Patrick C N YR 2017 UL http://drc.bmj.com/content/5/1/e000317.abstract AB Objective Rising global temperatures might contribute to the current worldwide diabetes epidemic, as higher ambient temperature can negatively impact glucose metabolism via a reduction in brown adipose tissue activity. Therefore, we examined the association between outdoor temperature and diabetes incidence in the USA as well as the prevalence of glucose intolerance worldwide.Research design and methods Using meta-regression, we determined the association between mean annual temperature and diabetes incidence during 1996–2009 for each US state separately. Subsequently, results were pooled in a meta-analysis. On a global scale, we performed a meta-regression analysis to assess the association between mean annual temperature and the prevalence of glucose intolerance.Results We demonstrated that, on average, per 1°C increase in temperature, age-adjusted diabetes incidence increased with 0.314 (95% CI 0.194 to 0.434) per 1000. Similarly, the worldwide prevalence of glucose intolerance increased by 0.170% (95% CI 0.107% to 0.234%) per 1°C rise in temperature. These associations persisted after adjustment for obesity.Conclusions Our findings indicate that the diabetes incidence rate in the USA and prevalence of glucose intolerance worldwide increase with higher outdoor temperature.