@article {Al Mansarie000519, author = {Abdulqawi Al Mansari and Youssef Obeid and Najmul Islam and Mohammed Fariduddin and Ahmed Hassoun and Khier Djaballah and Mojtaba Malek and Dror Dicker and Tirthankar Chaudhury}, title = {GOAL study: clinical and non-clinical predictive factors for achieving glycemic control in people with type 2 diabetes in real clinical practice}, volume = {6}, number = {1}, elocation-id = {e000519}, year = {2018}, doi = {10.1136/bmjdrc-2018-000519}, publisher = {BMJ Specialist Journals}, abstract = {Objective The American Diabetes Association and the European Association for the Study of Diabetes guidelines recommend to individualize treatment targets/strategies in inadequately controlled patients by lifestyle management and glucose-lowering drugs to decrease the burden of diabetes-related complications. This real-world practice study aimed to assess predictive factors for achieving the glycemic hemoglobin A1c (HbA1c) at 6 months as targeted by the treating physician in adults with type 2 diabetes who required initiation of basal insulin, initiation of bolus insulin, or modification from basal or premixed insulin to new insulin regimen containing insulin glargine and/or insulin glulisine.~Research design and methods This was an international, multicenter, observational survey with 12-month~follow-up time in adults with type 2 diabetes inadequately controlled conducted in 10 developing countries.~Results Overall, 2704 patients (mean age: 54.6 years, body mass index: 28.7 kg/m2; Caucasian: 46.1\%, type 2 diabetes duration: 10.1 years) with poor glycemic control (mean HbA1c: 9.7\% (83 mmol/mol), fasting blood glucose: 196.8 mg/dL) were eligible. At 6 months, advanced age, Caucasian ethnicity, shorter type 2 diabetes duration (\>10 vs 1 year, p\<0.0001), lower baseline HbA1c (>= 8.5\% vs \<7\%, p\<0.0001) and no intake of oral antidiabetic drug (OAD) (none vs 2, p=0.02) were predictive factors for achieving glycemic goal as targeted by the treating physician. Absolute changes in the mean HbA1c of -1.7\% and -2\% were observed from baseline to 6 and 12 months, respectively.~Conclusions Along with some well-known predictive factors, this study suggested that early insulin regimen treatment initiation and/or intensification allowed patients to promote glycemic control.}, URL = {https://drc.bmj.com/content/6/1/e000519}, eprint = {https://drc.bmj.com/content/6/1/e000519.full.pdf}, journal = {BMJ Open Diabetes Research and Care} }