PT - JOURNAL ARTICLE AU - Juan Ramón Gómez-Sandoval AU - José Antonio Robles-Cervantes AU - Sandra Ofelia Hernández-González AU - María Claudia Espinel-Bermudez AU - Rocío Mariaud-Schmidt AU - Vianeth Martínez-Rodríguez AU - Karina Celia Morgado-Castillo AU - Arieh Roldán Mercado-Sesma TI - Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial AID - 10.1136/bmjdrc-2019-000665 DP - 2020 Jan 01 TA - BMJ Open Diabetes Research & Care PG - e000665 VI - 8 IP - 1 4099 - http://drc.bmj.com/content/8/1/e000665.short 4100 - http://drc.bmj.com/content/8/1/e000665.full SO - BMJ Open Diab Res Care2020 Jan 01; 8 AB - Objective To determine the efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen during nonsurgical treatment of periodontitis in patients with type 2 diabetes mellitus.Research design and methods In this double-blind, randomized clinical trial, a total of 42 patients with chronic periodontitis and type 2 diabetes were included. Patients were randomly assigned to treatment with either clindamycin or amoxicillin-metronidazole three times a day during 7 days. Clinical determinations (probing depth, bleeding on probe, and plaque index) were performed to determine the extent and severity of periodontitis before and after the pharmacological treatment.Results After 7 days of administration of clindamycin or amoxicillin-metronidazole, no differences were observed between the clinical determinations, probing depth (0.44 vs 0.50 mm, p=0.624), plaque index (17.62 vs 15.88%, p=0.910), and bleeding on probing (16.12 vs 22.17%, p=0.163), respectively. There were no adverse events in either group.Conclusion The administration during 7 days of clindamycin or amoxicillin/metronidazole showed the same efficacy for the reduction of probing depth, plaque index, and bleeding on probing in patients with periodontitis and type 2 diabetes.