RT Journal Article
SR Electronic
T1 Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial
JF BMJ Open Diabetes Research & Care
JO BMJ Open Diab Res Care
FD American Diabetes Association
SP e000665
DO 10.1136/bmjdrc-2019-000665
VO 8
IS 1
A1 Gómez-Sandoval, Juan Ramón
A1 Robles-Cervantes, José Antonio
A1 Hernández-González, Sandra Ofelia
A1 Espinel-Bermudez, María Claudia
A1 Mariaud-Schmidt, Rocío
A1 Martínez-Rodríguez, Vianeth
A1 Morgado-Castillo, Karina Celia
A1 Mercado-Sesma, Arieh Roldán
YR 2020
UL http://drc.bmj.com/content/8/1/e000665.abstract
AB Objective To determine the efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen during nonsurgical treatment of periodontitis in patients with type 2 diabetes mellitus.Research design and methods In this double-blind, randomized clinical trial, a total of 42 patients with chronic periodontitis and type 2 diabetes were included. Patients were randomly assigned to treatment with either clindamycin or amoxicillin-metronidazole three times a day during 7 days. Clinical determinations (probing depth, bleeding on probe, and plaque index) were performed to determine the extent and severity of periodontitis before and after the pharmacological treatment.Results After 7 days of administration of clindamycin or amoxicillin-metronidazole, no differences were observed between the clinical determinations, probing depth (0.44 vs 0.50 mm, p=0.624), plaque index (17.62 vs 15.88%, p=0.910), and bleeding on probing (16.12 vs 22.17%, p=0.163), respectively. There were no adverse events in either group.Conclusion The administration during 7 days of clindamycin or amoxicillin/metronidazole showed the same efficacy for the reduction of probing depth, plaque index, and bleeding on probing in patients with periodontitis and type 2 diabetes.