RT Journal Article
SR Electronic
T1 Regional difference in the susceptibility of non-alcoholic fatty liver disease in China
JF BMJ Open Diabetes Research & Care
JO BMJ Open Diab Res Care
FD American Diabetes Association
SP e001311
DO 10.1136/bmjdrc-2020-001311
VO 8
IS 1
A1 Xia, Mingfeng
A1 Sun, Xiaoyang
A1 Zheng, Lili
A1 Bi, Yufang
A1 Li, Qiang
A1 Sun, Lirong
A1 Di, Fusheng
A1 Li, Hong
A1 Zhu, Dalong
A1 Gao, Yanyan
A1 Bao, Yuqian
A1 Wang, Yao
A1 He, Lanjie
A1 Wu, Bingjie
A1 Wang, Shanshan
A1 Gao, Jian
A1 Gao, Xin
A1 Bian, Hua
YR 2020
UL http://drc.bmj.com/content/8/1/e001311.abstract
AB Introduction Non-alcoholic fatty liver disease (NAFLD) is a global health problem with high geographic heterogeneity. We aimed to investigate regional-specific concomitant rate of NAFLD and quantitative relationship between liver fat content (LFC) and glucose metabolism parameters in representative clinical populations from six provinces/municipalities of China.Research design and methods A total of 2420 eligible Han Chinese were enrolled consecutively from 10 clinics of obesity, diabetes and metabolic diseases located at six provinces/municipalities of China, and divided into North (Tianjin, Shandong and Heilongjiang) and South (Shanghai, Jiangsu and Henan) groups according to their geographical latitude and proximity of NAFLD concomitant rate. LFC was assessed by a quantitative ultrasound method. Multivariate regression models and analysis of covariance were used to assess the regional difference in the risk of NAFLD.Results The concomitant rate of NAFLD was 23.3%, 44.0% and 55.3% in individuals with normal glucose tolerance (NGT), pre-diabetes and diabetes, respectively. A higher concomitant rate of NAFLD was found in the participants from the North comparing with the South group, regardless of glucose metabolism status (34.7% vs 16.2% in NGT, 61.5% vs 34.7% in pre-diabetes and 67.1% vs 48.1% in diabetes). This regional difference remained significant after adjustment for age, gender, alcohol drinking, cigarette smoking, confounding metabolic parameters and liver enzymes. For any given blood glucose, participants from the North had higher LFC than those from the South group.Conclusions Half of Han Chinese with pre-diabetes/type 2 diabetes had NAFLD, and the individuals from the North cities were more susceptible to NAFLD.