PT  - JOURNAL ARTICLE
AU  - Pilar Pérez-Segura
AU  - Olaya de Dios
AU  - Leticia Herrero
AU  - Claudia Vales-Villamarín
AU  - Isabel Aragón-Gómez
AU  - Teresa Gavela-Pérez
AU  - Carmen Garcés
AU  - Leandro Soriano-Guillén
TI  - Children with type 1 diabetes have elevated high-sensitivity C-reactive protein compared with a control group
AID  - 10.1136/bmjdrc-2020-001424
DP  - 2020 Jul 01
TA  - BMJ Open Diabetes Research & Care
PG  - e001424
VI  - 8
IP  - 1
4099  - http://drc.bmj.com/content/8/1/e001424.short
4100  - http://drc.bmj.com/content/8/1/e001424.full
SO  - BMJ Open Diab Res Care2020 Jul 01; 8
AB  - Introduction Our objective was to compare high-sensitivity C-reactive protein (hsCRP) levels in children with type 1 diabetes, healthy controls, and children with obesity. Additionally, we aimed to analyze the association between hsCRP levels and glycemic control measured by glycohemoglobin A (HbA1c) and anthropometric and biochemical variables.Research design and methods We conducted a non-randomized descriptive study of children with type 1 diabetes matched for sex and age with a control group and group with obesity. We recorded anthropometric parameters and studied variables related to diabetes, blood pressure, lipid profile, and HbA1c. hsCRP was measured by ELISA.Results We included 49 children with type 1 diabetes, 46 controls, and 40 children with obesity. hsCRP levels were significantly higher in the group with type 1 diabetes compared with controls and nearly significantly lower than in the group comprising children with obesity. We found no correlation between hsCRP and HbA1c and characteristics of type 1 diabetes with the exception of albumin to creatinine ratio. Statistically significant association was found between hsCRP and body mass index (BMI) and waist circumference Z-score.Conclusions The higher hsCRP levels observed in children with type 1 diabetes compared with a control group with a similar BMI suggest a basal inflammatory state that could increase cardiovascular risk. The main factors related to hsCRP are BMI and waist circumference, so obesity prevention should be a priority when performing follow-up in children with type 1 diabetes.