PT  - JOURNAL ARTICLE
AU  - Xiu-Ting Sun
AU  - Cheng Zeng
AU  - Shao-Zhao Zhang
AU  - Hui-Min Zhou
AU  - Xiang-Bin Zhong
AU  - Zhen-Yu Xiong
AU  - Da-Ya Yang
AU  - Yue Guo
AU  - Xiao-Dong Zhuang
AU  - Xin-Xue Liao
TI  - Long-term tracking of fasting blood glucose variability and peripheral artery disease in people without diabetes
AID  - 10.1136/bmjdrc-2019-000896
DP  - 2020 Sep 01
TA  - BMJ Open Diabetes Research & Care
PG  - e000896
VI  - 8
IP  - 1
4099  - http://drc.bmj.com/content/8/1/e000896.short
4100  - http://drc.bmj.com/content/8/1/e000896.full
SO  - BMJ Open Diab Res Care2020 Sep 01; 8
AB  - Introduction Long-term changes of fasting blood glucose (FBG) in relation to lower-extremity peripheral artery disease (lower-extremity PAD) in people without diabetes has barely been reported. Our study aimed to investigate the association between FBG variability and the incidence of lower-extremity PAD in people without diabetes.Research design and methods We included 7699 participants without prior lower-extremity PAD and diabetes from the Atherosclerosis Risk in Communities study in the final analysis. At least two measurements of FBG were required during follow-up. Variability of FBG was identified using SD, coefficient of variation (CV), variability independent of the mean (VIM) and average real variability. Lower-extremity PAD was defined as an ankle brachial index <0.9, or hospitalization with a lower-extremity PAD diagnosis. Cox regression model was used to calculate HR for incidence of lower-extremity PAD and FBG variability.Results During a median follow-up of 19.5 years, 504 (6.5 %) lower-extremity PAD events were observed, 54.4% (n=274) were male, and 17.5% (n=88) were African-American. FBG variability was positively associated with incident lower-extremity PAD, with a linear relationship. HRs for CV and VIM were 1.015 (95% CI: 1.001 to 1.03; p=0.023), and 1.032 (95% CI: 1.004 to 1.06; p=0.022) for lower-extremity PAD, respectively. Participants in the lowest quartile of CV were at lower lower-extremity PAD risk compared with the highest ones (HR: 1.499, 95% CI: 1.16 to 1.938; p=0.002).Conclusions Higher FBG variability was independently associated with increased prevalence of lower-extremity PAD in people without diabetes.Trial registration number NCT00005131.