PT - JOURNAL ARTICLE AU - Ayaka Tsuboi AU - Kaori Kitaoka AU - Megumu Yano AU - Mika Takeuchi AU - Satomi Minato-Inokawa AU - Mari Honda AU - Miki Kurata AU - Bin Wu AU - Tsutomu Kazumi AU - Keisuke Fukuo TI - Higher circulating orosomucoid, an acute-phase protein, and reduced glucose-induced insulin secretion in middle-aged Japanese people with prediabetes AID - 10.1136/bmjdrc-2020-001392 DP - 2020 Oct 01 TA - BMJ Open Diabetes Research & Care PG - e001392 VI - 8 IP - 2 4099 - http://drc.bmj.com/content/8/2/e001392.short 4100 - http://drc.bmj.com/content/8/2/e001392.full SO - BMJ Open Diab Res Care2020 Oct 01; 8 AB - Introduction Circulating orosomucoid, an acute-phase protein, predicted type 2 diabetes mellitus risk in several Western countries. Here, we assessed serum orosomucoid (ORM) in relation to prediabetes in the Japanese.Research design and methods Participants consisted of 83 middle-aged Japanese subjects with normal glucose tolerance (NGT), 37 with prediabetes and 4 with newly identified diabetes, whose homeostasis model assessment-insulin resistance (HOMA-IR) averaged 1.1±0.7, 1.4±0.9 and 1.7±0.8, respectively. Body composition, serum inflammatory markers, adiponectin, β-cell function and insulin resistance inferred from serum insulin kinetics during an oral glucose tolerance test were compared cross-sectionally between those with prediabetes and NGT.Results Serum orosomucoid, but not high-sensitivity C reactive protein, was elevated in prediabetes (190±29 vs 141±31 mg/dL) with further elevation in diabetes (295±52 mg/dL) (all p<0.001). Prediabetes was associated with lower Oral Disposition Index (the product of the Insulinogenic Index and Matsuda Index) with further depression in diabetes. No association was found with skeletal muscle mass, HOMA-IR, serum triglyceride, high-density lipoprotein (HDL) cholesterol and adiponectin.Conclusions Higher circulating ORM and reduced glucose induced insulin secretion were found in middle-aged Japanese people with prediabetes in the absence of insulin resistance.