TY - JOUR T1 - apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes JF - BMJ Open Diabetes Research & Care JO - BMJ Open Diab Res Care DO - 10.1136/bmjdrc-2020-001925 VL - 9 IS - 1 SP - e001925 AU - Manjunath Ramanjaneya AU - Alexandra E Butler AU - Mohammed Bashir AU - Ilham Bettahi AU - Abu Saleh Md Moin AU - Lina Ahmed AU - Mohamed A Elrayess AU - Steven C Hunt AU - Stephen L Atkin AU - Abdul Badi Abou-Samra Y1 - 2021/03/01 UR - http://drc.bmj.com/content/9/1/e001925.abstract N2 - Introduction Pregnant women with gestational diabetes mellitus (GDM) are at risk of adverse outcomes, including gestational hypertension, pre-eclampsia, and preterm delivery. This study was undertaken to determine if apolipoprotein (apo) levels differed between pregnant women with and without GDM and if they were associated with adverse pregnancy outcome.Research design and methods Pregnant women (46 women with GDM and 26 women without diabetes (ND)) in their second trimester were enrolled in the study. Plasma apos were measured and correlated to demographic, biochemical, and pregnancy outcome data.Results apoA2, apoC1, apoC3 and apoE were lower in women with GDM compared with control women (p=0.0019, p=0.0031, p=0.0002 and p=0.015, respectively). apoA1, apoB, apoD, apoH, and apoJ levels did not differ between control women and women with GDM. Pearson bivariate analysis revealed significant correlations between gestational age at delivery and apoA2 for women with GDM and control women, and between apoA2 and apoC3 concentrations and C reactive protein (CRP) as a measure of inflammation for the whole group.Conclusions Apoproteins apoA2, apoC1, apoC3 and apoE are decreased in women with GDM and may have a role in inflammation, as apoA2 and C3 correlated with CRP. The fact that apoA2 correlated with gestational age at delivery in both control women and women with GDM raises the hypothesis that apoA2 may be used as a biomarker of premature delivery, and this warrants further investigation.Data are available upon reasonable request. All underlying data relating to this study will be made available upon reasonable request to the corresponding author. ER -