TY - JOUR T1 - Insulin resistance versus insulin deficiency: evidence of racial differences in the pathogenesis of type 2 diabetes JF - BMJ Open Diabetes Research & Care JO - BMJ Open Diab Res Care DO - 10.1136/bmjdrc-2021-002261 VL - 9 IS - 1 SP - e002261 AU - Rajesh Garg Y1 - 2021/03/01 UR - http://drc.bmj.com/content/9/1/e002261.abstract N2 - Racial differences in the incidence of type 2 diabetes (T2D) are well established.1 Southeast Asians living in Western countries as well as those living in their native countries are at a higher risk of developing T2D as compared with the Whites.2 3 Similarly, Blacks and Native Americans in the USA are at a higher risk of developing T2D.4 Many studies have been conducted to understand the racial differences in the pathogenesis of T2D. Insulin resistance and insulin secretion defects have been the focus of most of these studies. South Asians, known to have more body fat for the same body mass index (BMI), have been shown to be more insulin resistant than Whites.5 6 Previous studies did not find South Asians to have higher degrees of insulin deficiency than Whites.7 However, two epidemiological studies in the current issue of BMJ-DRC suggest otherwise.8 9The first study compared the incidence of T2D in South Asians living in urban India and Pakistan with Blacks and Whites living in urban and suburban areas in the USA.8 South Asian data were obtained from the Cardiometabolic Risk Reduction in South Asia Study that recruited healthy … ER -