PT - JOURNAL ARTICLE AU - Jana L Slaght AU - Brandy Alexandra Wicklow AU - Allison B Dart AU - Elizabeth A C Sellers AU - Melissa Gabbs AU - Marylin Carino AU - Jonathan M McGavock TI - Physical activity and cardiometabolic health in adolescents with type 2 diabetes: a cross-sectional study AID - 10.1136/bmjdrc-2021-002134 DP - 2021 May 01 TA - BMJ Open Diabetes Research & Care PG - e002134 VI - 9 IP - 1 4099 - http://drc.bmj.com/content/9/1/e002134.short 4100 - http://drc.bmj.com/content/9/1/e002134.full SO - BMJ Open Diab Res Care2021 May 01; 9 AB - Introduction Youth living with type 2 diabetes display increased risk of cardiovascular disease (CVD). It is unclear if regular physical activity (PA) modifies this risk.Research design and methods We compared CVD risk factors in a cross-sectional study of 164 youth with type 2 diabetes stratified according to weekly vigorous-intensity PA. Outcomes were hemoglobin A1c (HbA1c), ambulatory blood pressure (BP; ambulatory 24-hour readings), plasma lipoproteins, and albuminuria. The main exposure, vigorous-intensity PA, was quantified with the Adolescent Physical Activity Recall Questionnaire.Results Youth were 15±3 years, and 78% lived rurally and 68% were female, with a mean body mass index (BMI) Z-score of 2.4±1.1 and a mean HbA1c of 9.6% ±2.6%. Youth who participated in regular vigorous-intensity PA (40%; n=67) achieved nearly twice the dose of PA than peers who did not (62 vs 34 metabolic equivalent score-hour/week, p=0.001). After adjusting for duration of diabetes, BMI Z-score, sex, and smoking, youth who engaged in vigorous-intensity PA displayed lower HbA1c (9.1% vs 9.9%, p=0.052), diastolic BP (70 mm Hg vs 73 mm Hg, p=0.002), diastolic load (20% vs 26%, p=0.023), and mean arterial pressure (87.3 mm Hg vs 90.3 mm Hg, p<0.01), compared with youth who did not. Compared with youth who did not participate in regular vigorous-intensity PA, those who did also displayed lower odds of albuminuria after adjusting for duration of diabetes, sex, smoking, rural residence, and BMI Z-score (adjusted OR: 0.40, 95% CI 0.19 to 0.84).Conclusions Among youth with type 2 diabetes, participation in vigorous-intensity PA is associated with lower CVD risk.Data are available upon reasonable request. Summary data are available upon request to the authors and are contingent upon approval from patient advisory and Indigenous data advisory committee for the iCARE cohort and DREAM theme, respectively. Requests can be made to dream@umanitoba.ca with reference to iCARE cohort study.