RT Journal Article
SR Electronic
T1 Physical activity and cardiometabolic health in adolescents with type 2 diabetes: a cross-sectional study
JF BMJ Open Diabetes Research & Care
JO BMJ Open Diab Res Care
FD American Diabetes Association
SP e002134
DO 10.1136/bmjdrc-2021-002134
VO 9
IS 1
A1 Jana L Slaght
A1 Brandy Alexandra Wicklow
A1 Allison B Dart
A1 Elizabeth A C Sellers
A1 Melissa Gabbs
A1 Marylin Carino
A1 Jonathan M McGavock
YR 2021
UL http://drc.bmj.com/content/9/1/e002134.abstract
AB Introduction Youth living with type 2 diabetes display increased risk of cardiovascular disease (CVD). It is unclear if regular physical activity (PA) modifies this risk.Research design and methods We compared CVD risk factors in a cross-sectional study of 164 youth with type 2 diabetes stratified according to weekly vigorous-intensity PA. Outcomes were hemoglobin A1c (HbA1c), ambulatory blood pressure (BP; ambulatory 24-hour readings), plasma lipoproteins, and albuminuria. The main exposure, vigorous-intensity PA, was quantified with the Adolescent Physical Activity Recall Questionnaire.Results Youth were 15±3 years, and 78% lived rurally and 68% were female, with a mean body mass index (BMI) Z-score of 2.4±1.1 and a mean HbA1c of 9.6% ±2.6%. Youth who participated in regular vigorous-intensity PA (40%; n=67) achieved nearly twice the dose of PA than peers who did not (62 vs 34 metabolic equivalent score-hour/week, p=0.001). After adjusting for duration of diabetes, BMI Z-score, sex, and smoking, youth who engaged in vigorous-intensity PA displayed lower HbA1c (9.1% vs 9.9%, p=0.052), diastolic BP (70 mm Hg vs 73 mm Hg, p=0.002), diastolic load (20% vs 26%, p=0.023), and mean arterial pressure (87.3 mm Hg vs 90.3 mm Hg, p<0.01), compared with youth who did not. Compared with youth who did not participate in regular vigorous-intensity PA, those who did also displayed lower odds of albuminuria after adjusting for duration of diabetes, sex, smoking, rural residence, and BMI Z-score (adjusted OR: 0.40, 95% CI 0.19 to 0.84).Conclusions Among youth with type 2 diabetes, participation in vigorous-intensity PA is associated with lower CVD risk.Data are available upon reasonable request. Summary data are available upon request to the authors and are contingent upon approval from patient advisory and Indigenous data advisory committee for the iCARE cohort and DREAM theme, respectively. Requests can be made to dream@umanitoba.ca with reference to iCARE cohort study.